AKT Pharmacology

Question 1

Sildenafil (Viagra)

Answer 1

Side effects:
- Flushing
- Headache
- Nasal congestion
- GI side effects
- Blue vision ‘blue pill’

Contraindications
- With nitrates or nicorandil
- Hypotension
- Within 6 months of MI or stroke

Question 2

Aspirin

Answer 2

Side effects
- Urticaria

Question 3

Drugs To be Prescribed by Brand

Answer 3

• MR calcium channel blockers
• AED
• Ciclosporin and tacrolimus
• Mesalazine
• Lithium
• Aminophylline and Theophylline
• Methylphenidate
• CFC-free formulations of beclometasone
• Dry powder inhaler devices

Question 4

Diclofenac

Answer 4

• Contraindicated with any form of cardiovascular disease

Question 5

Ecstasy (MDMA)

Answer 5

Features
- Agitation, anxiety, confusion, ataxia
- Tachycardia, hypertension
- Hyperthermia
- Hyponatraemia
- Rhabdo

Question 6

Digoxin

Answer 6

Drugs increase risk of digoxin toxicity
- Diltiazem and verapamil
- Diuretics

Question 7

Metformin

Answer 7

• Stop day of contrast scan and restarted 48 hours after

Question 8

Ciprofloxacin

Answer 8

Ciprofloxacin lowers seizure threshold

Question 9

Omeprazole

Answer 9

PPIs can cause low magnesium

Question 10

PPI

Answer 10

Can cause low Mg

Question 11

Amiodarone

Answer 11

Side effects
- Thyroid disease
- Pulmonary fibrosis
- Corneal deposits
- Liver fibrosis/hepatitis
- Peripheral neuropathy
- Photosensitivity
- Slate grey appearance
- Thrombophlebitis at injection sites
- Bradycaedia
- Prolonged QTc

Drug interactions
- Increases digoxin levels
- Decreases metabolism of warfarin

Question 12

Beta blockers

Answer 12

Reduce hypoglycaemic awareness

Question 13

Chloramphenicol

Answer 13

Do not give to patients taking bone marrow suppression drugs eg methotrexate

Question 14

Ciclosporin

Answer 14

Side effects - everything is increased - hypertension, hyperkalaemia, hypertrichosis, fluid overload, gingival hyperplasia, hyperglycaemia, hyperlipidaemia

Question 15

Ciprofloaxacin

Answer 15

Tendonopathy - Achilles tendinitis