AKI NHBR Flashcards
What is the mechanism of bath salt nephropathy?
Hyperuricaemia
Rhabdomyolysis
What FE Urea indicates pre-renal AKI as opposed to ATN?
<35%
What are the sub-types of CRS?
Type 1: ADHF --> AKI Type 2: CCF --> CKD Type 3: AKI --> ADHF Type 4: CKD --> CCF Type 5: Secondary CRS (sepsis)
What is the benefit of pentoxyfylline in patients with alc hepatitis?
May reduce the risk of HRS but not short-term survival
What is terliepressin?
Synthetic vasopressin 1a agonist
What is the definition of IAH?
IAP ≥ 20mmHg or APP ≤ 60 where APP = MAP - IAP
What is seen on the histology of Contrast Associated Nephropathy?
Vacuolisation in the proximal tubules
What did the POISEIDON trial find?
That fluid therapy guided by LV end diastolic pressure reduced the risk for CI-AKI
What are the high risk malignancies for TLS?
Burkitt Lymphoma
ALL
AML
DLBCL with a LDH ≥ 2 ULN
What are the electrolyte abnormalities in TLS?
Hyperkalaemia
Hypocalcaemia
Hyperuricaemia
Hyperphosphataemia
How does TLS cause AKI?
- Uric acid
- causes crystallopathy
- causes ATIN
- causes reduced renal perfusion - Hyperphosphataemia
- associated with Ca Oxalate crystals
What is the MoA for rasburicase?
Converts UA to allantoin, a soluble metabolite that is excreted renal
Reduces UA level but no evidence to show that it genuinely reduces the risk of TLS
In whom is rasburicase CI?
Those with G6PD and catalase deficiencies… leads to haemolytic anaemia and methaemoglobinaemia, respectively.
What are the biopsy findings in a patient with Hantavirus induced AKI?
- TIN and ATN
- Intersitial oedema
- Medullary haemorrhage
What % of women with postpartum aHUS develop ESKD?
70-80%