AKI & CKD Flashcards
What is the definition of AKI?
A clinical syndrome characterised by an abrupt reduction in kidney function in a previous normal kidney
What are the different stages of AKI?
STAGE 1: Absolute ↑Creatinine >26 within 48hours OR >50%↑ in Creatinine from baseline in 7d OR 25%↓ in eGFR in 7days OR UO <0.5ml/kg/hr for >6hours
STAGE 2: Creatinine >2-3x baseline OR eGFR >50% or UO <0.5ml/kg/hr for >12hrs
STAGE 3: Cr >354 OR >x3 baseline OR eGFR >70% OR UO < 0.3ml/kg/hr for 24hours OR use of RRT
What signs can show the severity of an AKI?
- Fluid overload: Pulmonary crackles, ↑JVP, peripheral oedema, gallop rhythm
- Fluid depletion: Postural hypoT (<90/60), tissue turgor, dry mucous membranes, sunken eyes
- Urine output: Oligo/anuria
- HyperK
- Acidosis
What are the signs of hyperK on an ECG?
Tall tented T-waves Flat P waves Broad QRS Sliping ST Sine wave ECG
How are 80% of cases of AKI resolved?
Fluid assessment & replacement
Tx acidosis
Tx sepsis
STOP nephrotoxic drugs
What are the pre-renal causes of AKI?
Hypovolaemia (HF, blood/fluid loss, D&V) Sepsis RAS (worse w/ACEi) Nephrotic syndrome Nephrotoxic drugs
Which drugs are nephrotoxic?
Vasomotor nephropathy: ACEi, ARB, NSAIDs
Allergy: NSAIDs, Abx: Trimethoprim, Vancomycin, ahminoglycosides
Direct nephrotoxicity: Gentamicin, Contrast
Diuretics
↑risk of toxicity: Metformin, Lithium, Digoxin
What are the renal/intrinsic causes of AKI?
GN Acute tubular necrosis Acute interstitial nephritis Thrombotic microangiopathy Rhabdomyolysis Tumour lysis Myeloma
What are the post-renal causes of AKI?
Ureteric stones
Ureteric retroperitoneal fibrosis/tumour
BPH
RTA
What are the indication for dialysis?
AEIOU A: Metabolic acidosis E: Electrolyte disturbance I: Intoxication O: Overload U: Uraemia (pericarditis, encephalopathy, bleeding)
How is an AKI investigated?
Bloods: FBC, U&E, LFT (↑ALP), ESR/CRP, Ca2+, CK, Coag, K+
Urine dip: Protein, blood, leukocytes, nitrates +/- MC&S
ABG: Metabolic acidosis
Immunology screen: ANCA, ANA, anti-GBM, ASO titre, Complements
ECG: HyperK
USS: In 24hrs if obstruction
How is AKI treated?
HOLD nephrotoxic drugs
HOLD K+ supplements
How is hyperkalaemia treated?
Calcium gluconate: 30ml in 10% bolus IV REPEAT every 20mins until ECG normalises
Insulin: Actrapid 10u in 50ml of 50% Dextrose
Salbutamol: 5mg news x4
Calcium resonium: 15g PO TDS
Haemodialysis
In AKI how is acidosis treated?
IV Bicarb: 50-100ml 8.4% in 30mins
How is an obstructive AKI treated?
Catheter- monitor UO
USS ASAP