AKI and CKD 1

Question 1

1. What is normal GFR?

Answer 1

120 mL/min (7.2 L/hour)

Question 2

3. Define clearance.

Answer 2

The volume of plasma that can be completely cleared of a marker substance per unit time

Question 3

4. What are the three criteria for a marker to be used to measure GFR?

Answer 3

Marker is not bound to serum proteins
Freely filtered by the glomerulus
Not secreted or absorbed by tubular cells

Question 4

5. State the equation that links clearance with urine and plasma concentration.

Answer 4

C = (U x V/P)

Question 5

7. Name three single injection plasma clearance markers.

Answer 5

51Cr-EDTA
99Tc-DTPA
Iohexol