Airway Flashcards
T/F
breathing can be performed exclusively by the diaphragm
True
in normal lungs this is possible
In the adult, the tip of an orotracheal tube moves an average of __ cm with flexion/extension of the neck, but can travel as much as ___ cm. In infants and children, displacement of even __ cm can move the tube above the vocal cords or below the carina
In the adult, the tip of an orotracheal tube moves an average of 3.8 cm with flexion/extension of the neck, but can travel as much as 6.4 cm. In infants and children, displacement of even 1 cm can move the tube above the vocal cords or below the carina
When ____ is reduced, larger changes in pleural pressure are needed to create the same tidal volume (Vt).
lung compliance
Patients with low lung compliance breathe with (smaller/larger) Vt and more rapidly, making spontaneous ____ the most sensitive clinical index of lung compliance.
smaller Vt
respiratory rate
Carotid and aortic bodies are stimulated by ____ values less than ____.
Thus, patients who depend on hypoxic ventilatory drive must have PaO2 values below ____.
PaO2
60 to 65 mmHg
65 mmHg
The three etiologies of hyperventilation
arterial hypoxemia
metabolic acidemia
central etiologies (e.g., intracranial hypertension, hepatic cirrhosis, anxiety, pharmacologic agents).
Increases in dead space ventilation primarily affect ____ elimination (with minimal influence on arterial oxygenation)
Increases in physiologic shunt primarily affect ____ (with minimal influence on CO2 elimination).
Increased dead space ventilation affects CO2 elimination
Increased shunt affects arterial oxygenation
*dead space: volume of ventilated air that does not participate in gas exchange; fills the conducting zone of respiration made up by the nose, trachea, and bronchi
alveolar ventilation : dead space ventilation ratio
What is it during spontaneous breathing?
What is it during during positive-pressure ventilation?
2:1
1:1
*When on vent, need higher minute ventilation than during spontaneous ventilation to achieve the same PaCO2.
PaCO2 ≥ PETCO2 unless the patient inspires/receives…
exogenous CO2
The difference between PaCO2 and PETCO2 is due to…
dead space ventilation
The most common reason for an acute increase in dead space ventilation is…
decreased cardiac output
What happens with reduced functional residual capacity (FRC)?
-tachypnea (reduced lung compliance )
-arterial hypoxemia (venous admixture increases)
The thoracic cage is shaped like…
a truncated cone
small superior aperture
larger inferior opening (attaches to diaphragm)
Thorax
horizontal plane that passes through the vertebral column at…
T4 or T5
Thorax
The horizontal plane separates which two structures?
the superior from the inferior mediastinum
During ventilation, the upper thoracic diameter mostly changes in the ____ direction & the lower thorax changes in the ____ direction.
thoracic diameter changes:
upper thorax: anteroposteriorly
lower thorax: lateral/transverse
Work of breathing is the energy expenditure of ___.
ventilatory muscles
Ventilatory muscles are ____ muscles. They are susceptible to ____.
endurance
fatigue
Some causes of respiratory fatigue
inadequate oxygen delivery
poor nutrition
increased work secondary to COPD with gas trapping or increased airway resistance
ventilatory muscles (7)
- diaphragm
- intercostal muscles
- abdominal muscles
- cervical strap muscles
- sternocleidomastoid muscles
- back muscles
- intervertebral muscles of the shoulder girdle
The diaphragm performs most of the muscle work during….
nonstrenuous breathing
Exhalation is usually (active/passive).
passive
Patients with c-spine injurty rely on which muscles to breathe?
rely on abd & back muscle
the cervical strap muscles are not working
(Increased work of breathing)
Initial increase will require help from ____ muscles. Further increase in WOB recruits ____ muscles. Maximal work incorporates ____ muscles.
Initial: abdominal muscles rib depression, forced exhalation (felt as rib pain when atheletes forcibily exhale)
Further: cervical strap muscles(elevate sternum & upper chest = optimize thoracic dimensions)
Maximal work: back & paravertebral muscles of the shoulder girdle
Most powerful muscles of expiration
muscles of the abdominal wall
ie: coughing
____ twitch muscles are most susceptible to fatigue.
fast
(“the fast and fatigued”)
What creates negative pressure in the intrapleural space?
diaphragm descends
ribcage expands
Functional residual capacity (FRC)
Definition
The volume of gas remaining in the lungs at PASSIVE end-expiration
created by equal and opposing forces at end-inspiration
At FRC, the intrapleural space has a slightly subambient pressure of…
-2 to -3 mmHg
The 3 divisions of lung parenchyma
Which airway division is responsible for bulk gas movement?
conductive
T/F
Gas exchange occurs in the transitional airways.
True
Transitional airways: gas movement, limited gas diffusion and exchange.
T/F
Gas exchange occurs in the smallest respiratory airway.
True
the primary function of the smallest respiratory airways is gas exchange
The trachea is part of the ____ airway division.
conductive
(T/F)
The transitional airway division contains the alveolar sacs.
False.
The respiratory airway contains the alveolar sacs.
The transitional airway division contains the alveolar ducts.
Which airway are the alveoli located in?
Respiratory
Alveoli and their sacs are in the respiratory airway.
R & L Mainstem bronchi
Which bronchus has the greater diameter?
Angles of each?
Which has longer length before the branching point?
right bronchus has larger diameter
right bronchus leaves the trachea at 25 degrees (less acute)
left bronchus is about 45 degrees.
right main bronchus ~2.5 cm long
left main bronchus ~5 cm
T/F
In all populations, endobronchial intubation and aspiration are more likely in the right bronchus.
False
<3 Y/O: bronchi angles are about equal (55 degrees)
Dr H: “it’s a crapchute where it goes”
The last airway component incapable of gas exchange
bronchioles
First site in the tracheobronchial tree where gas exchange occurs?
respiratory bronchiole
note how it follows the terminal bronchiole
(you’d think terminal means last but w/e)
Alveolar sacs open into what structure?
alveolar clusters
terminal bronchiole > respiratory brionchiole (gas exch starts) > alveolar ducts > alveolar sacs > alveolar clusters
Alveolar-capillary membrane has two primary functions. What are they?
- transport of respiratory gases (oxygen and carbon dioxide)
- production of a wide variety of local and humoral substances
“I’m good at 2 things: breathing and being hormonal”
Surfactant
keeps alv. membrane open
needed for gas exch.
Pulmonary Vascular System Flow
mixed-venous blood RV –> pulmonary capillary bed via two pulmonary arteries
gas exchange occurs in the pulmonary capillary bed
blood is returned to the left atrium via four pulmonary veins
How many pulmonary arteries do we have? how many veins?
2 arteries
4 veins
looks like we prioritize transport of O2 rich blood
What provides oxygen to the conductive airways and pulmonary vessels?
The bronchial arterial system
similar to how the heart has coronary arteries
What determines the lung’s response to external forces?
two main characteristics:
1. ease of elastic recoil of the chest wall
2. resistance to gas flow within airways
Response = recoil & resistance
“R & R”
The natural tendency of the lungs is to…
collapse due to elastic recoil
Older people have (more/less) recoil.
Less recoil
Asthma (increases/decreases) airway resistance.
increases
Physiologic work of breathing includes which types of work? What are they for?
elastic work (inspiratory work; overcome the elastic recoil of the pulmonary system)
resistive work (work to overcome resistance to gas flow in the airway)
What is shown from the pressure-volume relationship of the thorax and lungs?
how normal breathing relates pressure (Vt) to curves when illness affects breathing
Pressure-volume relationship of thorax and lung results in a ___ curve
sigmoidal
How do we find FRC on a pressure-volume relationship?
vertical line drawn at end-expiration coincides with FRC
(Pressure-volume relationship)
Humans breathe on which part of the sigmoid curve? What does this tell us?
The steepest part
shows total lung capacity
(Pressure-volume relationship)
What causes right shift of the compliance curve?
restrictive Dz (less FRC and Vt)
Restrictive = Right shift
T/F
Decreased lung compliance = larger FRC.
False
Decreased lung compliance results in lower FRCs.
Compliance inversely r/t elastic recoil
High compliance = pliable
ie: grocery bag; easy inflation, no elastic recoil
Low compliance = stiff
ie: thick balloon; hard to inflate, high elastic recoil
Increase lung compliance requires (less/more) elastic work to inspire & have (increased/decreased) elastic recoil. This ultimately leads to….
higher compliance:
-less elastic work to inspire
-decreased elastic recoil
result: larger than normal FRC (gas trapping)
High compliance lung = plastic bag
What can cause active exhalation?
high FRC & compliance; gas trapping
COPD & asthma
active exhalation: must use ventilatory muscles to exhale
Diseases characterized by high compliance
COPD
acute asthma
Gas trapping is seen in elevated ____.
FRC
⭐️
What do we need to measure to determine compliance and inspiratory elastic work per breath
airway pressure (Paw)
intrapleural (Ppl) pressure
tidal volume
Laminar Flow Characteristics
-zero velocity at container wall
-maximum velocity at the center of the advancing “cone”.
-conical front: some fresh gas reaches the end of the tube before its completely filled
Laminar flow in the airways allows…
alveolar ventilation even when the tidal volume (Vt) is less than anatomic dead space
(conical front: some fresh gas reaches the end of the tube before its completely filled)
Which type of flow is audible? Which is inaudible?
Audible: turbulent
Inaudible: laminar
Four conditions that will change laminar flow to turbulent flow
- high gas flows
- sharp angles within the tube
- branching/irreg shape in the tube
- decrease in tube diameter
Relationship between resistance and gas flow rate in laminar and turbulent flow
laminar flow
⬆️ resistance = ⬇️ flow rate. (inversely proportional)
turbulent flow
⬆️ flow rate = ⬆️ resistance significantly in proportion
The conscious subject can detect small increases in…
inspiratory resistance
The normal response to increased inspiratory resistance is…
increased inspiratory muscle effort
little change in FRC
An asthmatic pt is showing increased PaCO2 in the setting of increased airway resistance. What does this tell us?
the patient’s compensatory mechanisms are nearly exhausted
acute ventilatory failure!
asthmatic pts can usually compensate for increased airway resistance and keep their paCO2 in the lower normal range
Can asthmatic pts compensate for increased airway resistance? What happens to their PaCO2?
Yes
PaCO2 stays in the low normal range
***PaCO2 = measured the partial pressure of carbon dioxide in arterial blood.
Increased airway resistance may indicate/result from…
BRONCHOSPASM
musocal edema/plug
epitheal desquamination
tumors
foreign bodies
How does recoil affect FRC?
less recoil = high FRC (and residual volume)
How does compliance affect WOB?
diminished compliance of the chest wall = increased WOB
“Noncompliant pts are more work”
Age related changes in respiratory fxn
decreased recoil (elastance)
increased residual vol
increased FRC
decreased chest wall compliance (higher WOB)
usually normal gas exch at rest & exertion
modest decrease in PaO2
no change in PaCO2
decreased sensitivity to hypoxemia and hypercapnia; blunted ventilatory response when challenged by heart failure, airway obstruction, or pneumonia
⭐️
Breathing
act of inspiring and exhaling
requires energy for muscle work
limited by energy reserves
⭐️
Inhalation induction would be (ventilation/respiration).
ventilation
⭐️
Ventilation
movement of gas in and out of the lungs
⭐️
Respiration
- energy is released from organic molecules
- dependent on the movement of gas molecules (CO2 & O2) across membranes
⭐️
humans breathe to _____ and ventilate to ______.
we breathe to ventilate
we ventilate to respire
⭐️
Eupnea
good breathing!
continuous inspiratory and expiratory movement without interruption
⭐️
Apnea
“No breathing”: cessation of ventilatory effort at passive end-expiration (lung volume = FRC)
⭐️
When is lung volume equal to FRC?
during apnea
⭐️
Apneusis
TB definition: Cessation of ventilatory effort with lungs filled at TLC
Google: prolonged, gasping inhalations followed by extremely short and inadequate exhalations.
⭐️
Apneustic ventilation
Apneusis with periodic expiratory spasms
Dr. H: full lungs w/ periodic exp. spasms
⭐️
Biot
Ventilatory gasps interposed between periods of ventilation apnea; also “agonal ventilation”
biot = ‘bouta meet Jesus
Where are the most basic ventilatory control centers?
medulla oblongata
Dorsal Respiratory Group (DRG)
pacemaker for respiratory system
source of elementary ventilatory rhythmicity
“PACE the DRG so you don’t kill the pt”
ventral respiratory group (VRG)
ventral medullary reticular formation
serves as the expiratory coordinating center
How do DRG and VRG control breathing?
-DRG= impulse to inspire
-inspiration occurs
-DRG impulse quenched by a reciprocating VRG impulse
-VRG prohibits further use of the inspiratory muscles
-passive expiration
pneumotaxic respiratory center
limits the depth of inspiration
“the PNEUMOTAXI will take us this DEEP into the city”
peripheral chemoreceptors are composed of…
the carotid and aortic bodies
Where are the carotid bodies? What do they do?
located at the bifurcation of the common carotid artery
predominantly ventilatory effects
How do the carotid bodies control ventilation?
- reaches the central respiratory centers via the afferent glossopharyngeal nerves
- stimulated by decreased PaO2
-PaO2 must reach 60 to 65 mmHg to increase neural activity to substantially augment minute ventilation
“C.I.M.V. (Candy in my van)
Carotid Bodies Increase Minute Ventilation”
During withdrawal of mechanical ventilatory support in a patient who depends on hypoxic ventilatory drive, the PaO2 must fall to less than __ mmHg for spontaneous ventilation to resume.
65
When do the carotid bodies increase minute ventilation?
PaO2 must decrease to 60-65 mmHg
80% of the ventilatory response to inhaled carbon dioxide originates in the…
central medullary centers
Acid–base regulation involving carbon dioxide, H+, and bicarbonate is related primarily to…
chemosensitive receptors located in the medulla
(central chemoreceptors)
Central Chemoreceptors characteristics
-ventilatory response to inhaled anesthetics
-acid-base regulation
-sensitive to ECF H+ [ ]
(Acid-base regulation)
Carbon dioxide has a potent but indirect effect by reacting with water to form ____, which dissociates into ___ & _____ ions.
CO2 + H2O = carbonic acid
carbonic acid dissociates –> H & bicarb ions
Which passes readily through the blood–brain and blood–CSF barriers?
CO2
H+
Carbon dioxide
Which is a more potent ventilatory stimulus?
-acute increase in PaCO2
-acute increase in arterial H+ [ ] from a metabolic source
An acute increase in PaCO2
Carbon dioxide, but not H+, passes readily through the blood–brain and blood–CSF barriers
What are the ventilatory responses to changes in PaCO2?
Onset?
Duration?
increased Vt
increased respiratory rate
rapid; peaks within 1 to 2 minutes after an acute change in PaCO2
increase in ventilation declines over a period of several hours (if CO2 stimulant persists)
Desaturation in a healthy patient takes how long? De-nitrogenating buys us how much time?
3-4 mins
wash out nitro can buy us 10 mins of apnea (in healthy pts)
Breathing 100% oxygen prior to breath-holding
-how long can pt be apneic?
2 to 3 minutes
or
until PaCO2 rises to 60 mmHg
⭐️
Innervation of the Larynx
2 Branches of the Vagus Nerve innervate the Larynx
Superior Laryngeal Nerve
Recurrent Laryngeal Nerve- supply all of the Intrinsic Muscles of the larynx (except the cricothyroid)
SCAR
Super laryngeal
Cricothyroid muscle
All other muscles
Recurrent Laryngeal
Hyperventilation with 100% FiO2 extends the apenic period from ___ minutes to ___ minutes.
3-4
6-10
The rate of PaCO2 rise in awake, preoxygenated adults with normal lungs who hold their breath without previous hyperventilation is ___ mmHg/min in the first 10 seconds, ___ mmHg/min in the next 10 seconds, and ___ mmHg/min thereafter.
7
2
6
⭐️
What causes the CO2 rise in apneic patients under general anesthesia?
“breath-hold” at FRC rather than at vital capacity, which tends to accelerate the rate of PaCO2 rise
However, CO2 rise is still slower than awake state
⭐️
PaCO2 rises in apneic anesthetized patients is __ mmHg during the first minute and __ mmHg/min thereafter
12
3.5
⭐️
Which pt would have a faster rise in CO2? Why?
-apneic under general anesthesia
-pre-oxygenated, awake
Rate of rise of PaCO2 in apneic anesthetized pt is slower than awake state
metabolic rate and carbon dioxide production are significantly less when under anesthesia
lower rate of PaCO2 rise under anesthesia.
T/F
If pt is refusing supplemental O2, hyperventilation with room air can be performed.
False
hyperventilation before prolonged breath-holding can cause loss of consciousness due to arterial hypoxemia
blow off all CO2 = no stimulus to breathe
Is it okay to give aggressive intermittent positive-pressure breathing treatments for patients with COPD?
Nah (if they have a carbon dioxide–based ventilatory drive)
it can depress minute ventilation sufficiently to create arterial hypoxemia
T/F
Lung capacities are based on weight.
False
height
Capacities are composed of….
2+ lung volumes
Tidal Volume (Vt)
volume of gas that moves in and out of the lungs during quiet breathing
~ 6 to 8 mL/kg
“tidal volume; think of tides moving in AND out”
What would decrease tidal volume (Vt)?
decreased lung compliance
reduced ventilatory muscle strength
less flexibility and strength = less Vt
Vital capacity (VC)
Definition
Normal value
Google: the volume of exhaled air after maximal inspiration
60 ml/kg
can vary ~20% in healthy ppl
deep breathing and effective coughing. It is decreased by restrictive pulmonary disease such as pulmonary edema or atelectasis
What would decrease vital capacity (VC)?
restrictive pulmonary disease
-pulmonary edema
-atelectasis
mechanically induced, extrapulmonary restriction:
-pleural effusion
-pneumothorax
-pregnancy
-large ascites
-ventilatory muscle weakness
Things that would press against you exhaling
Inspiratory capacity
largest volume of gas that can be inspired from the resting expiratory level
decreased: significant extrathoracic airway obstruction; obesity
“relax. now take the deepest breath you can”
Residual volume
gas remaining within the lungs at the end of forced maximal expiration; cannot get any more air out
(Residual=what’s left over)
The 2 fxns of FRC on curve
1.resting ventilation on the pulmonary volume–pressure curve
2.elastic pressure–volume relationships in the lung
greatly influences ventilation–perfusion relationships within the lung!
primary determinant of oxygen reserve in humans when apnea occurs
FRC
resting expiratory volume of the lung
FRC
What can FRC tell us (not regarding the curve)
-quantify the degree of pulmonary restriction
-primary determinant of oxygen reserve in humans when apnea occurs
-resting expiratory volume of the lung
Reduces FRC
acute lung injury
pulmonary edema
pulmonary fibrotic processes
atelectasis
(these also reduce compliance)
pregnancy
obesity
pleural effusion
posture
The ____ decreases 10% when a healthy subject lies supine.
FRC
T/F
COPD increases compliance.
True
due to gas trapping
lungs recoil less forcibly
Gas Trapping
retain an abnormally large volume at the end of passive expiration
Forced vital capacity (FVC)
volume of gas that can be expired as forcefully and rapidly as possible after maximal inspiration.
Normally, FVC is equal to vital capacity
FVC may be reduced in…
-chronic obstructive diseases (even if vital capacity is ~normal).
-restrictive diseases
FVC values lower than __ mL/kg are associated with an increased incidence of post-op pulmonary complications (PPCs).
15
and its your fault ;)
Forced expiratory volume (FEVT)
Definition
what does it tell us?
forced expiratory volume of gas over a given time interval during the FVC maneuver
Dr. H: the most gas you can exhale over a time period
-measures flow and severity of airway obstruction!
The most important application of FEVT is…
The most common FEVT?
its comparison with the patient’s FVC
normal: expire 75%+ of FVC in one second
most common: FEVT1 (1 second)
Normal results for FEVT
0.5 sec: expire 50% to 60% of FVC
1 sec: 75% to 85%
2 sec: 94%
3 sec: 97%
tldr: normally, we can forcibly expire nearly all FVC in ~3 secs
reduced= obstructive Dz
FEF25%–75%
“maximum mid-expiratory flow rate”
average forced expiratory flow during the middle half of the FEV maneuver
length of time required for a subject to expire the middle half of the FVC is divided into 50% of the FVC.
Airway management always begins with…
A thorough airway-relevant history and physical examination.
Preoxygenation is also known as…
denitrogenation
should be practiced in all cases when time allows
What is the goal of direct laryngoscopy?
direct line of sight to the larynx
Videolaryngoscopy
mimics direct laryngoscopy, but places an imaging device toward the distal end of the laryngoscope blade
moves the provider’s point of view past the tongue, avoiding the need for a direct line of sight to the glottis
Steps for favorable airway outcome
(1) thorough airway history and physical examination
(2) direct or indirect laryngoscopy
(3) preinduction plan that includes supraglottic ventilation (e.g., facemask supraglottic airway [SGA])
(4) aspiration risk
(5) risk of failed airway maneuvers
Airway
refers to the upper airway
-nasal cavity
-oral cavities
-pharynx
-larynx
-trachea
-principal bronchi
Say pharnyx/larnyx so we can see Dr. H throw the shoe!
The airway in humans is primarily a ___ pathway.
conducting
We want our thyromental distance to be…
3+ finger breadths
The laryngeal skeleton consists of ___ cartilages. It houses the ___.
nine (3 paired; 3 unpaired)
vocal folds
⭐️
Movement of the laryngeal structures are controlled by…
two groups of muscles:
extrinsic muscles- move the larynx as a whole
intrinsic muscles- move the cartilages in relation to one another
⭐️⭐️⭐️
The larynx is innervated by the…
superior and recurrent laryngeal nerves (branches of the vagus nerve)
⭐️
Supplies all of the intrinsic muscles of the larynx (with the exception of cricothyroid muscle)
Recurrent
SCAR
Superior laryngeal nerve
Cricothyroid
All other muscles
Recurrent laryngeal nerve
Unilateral recurrent laryngeal nerve injury
hoarseness
aspiration risk!
Bilateral laryngeal nerve injury
risk complete airway obstruction due to fixed cord adduction (surgical emergency)
Cricothyroid membrane (CTM)
where it at
what it do
1 to 1.5 fingerbreadths below the laryngeal prominence (thyroid notch)
below thyroid cartilage & above cricoid cartilage
coverage for cricothyroid space
Any incisions or needle punctures to the CTM be made in…
its inferior third
directed posteriorly (a posterior probing needle will strike the back side of the ring-shaped cricoid cartilage)
How long is the adult trachea?
where does it end?
15 cm
ends @ t5; carina
bifurcates into R & L principal bronchi
Which bronchi deviates from the sagittal plane at a less acute angle?
right principle bronchus
part of why accidental intubation and aspiration are more common here
Edentulous patients pose what challenge to airway management?
(no teeth)
difficult mask ventilation
Thyromental distance reflects…
neck mobility
degree of retrognathia (bull-dog look)
remember, we want 3 finger breadths!
Thyromtental distance: tip of mentum to thyroid notch in neck-extended position