AIDS, MODS, SIRS, HIV Flashcards
effects of aging on the immune system
- increase incidences of tumors
- greater susceptibility to infection
- decrease in cell-mediated immunity
- decrease in proliferation response of t and b cells
- decrease in primary and secondary antibody responses
- decrease in autoantibodies
clinical manifestations of normal inflammation response
- malaise & fever
- Nausea and anorexia
- increased pulse and RR
SIRS
an inflammatory state affecting the while body, f
it is related to sepsis
it is the body’s response to an infectious or noninfectious insult
what do you see with SIRS?
- excessive vasodilaiton
- increase microvascular permeability
- exaggerated cellular activation
- accelerated coagulation
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clinical manifestations of SIRS
2 of the following
- temp of >100.4 or 90
RR > 20
WBC > 12,000 or 10% bands
what equals sepsis?
SIRS + confirmed infection
pre-existing contributing factors to SIRS
- age
- chronic disease states
- severity of initial insult
- immunosuppression
What organ is effected in SIRS and what lab value to look at?
Kidneys Creatinine (0.5-1.5) when kidneys function slow these levels rise
MODS definition
A progressive failure of > 2 organ systems resulting from malignant intravascular inflammation & resultant tissue hypoxia
Primary causes of MODS
- sepsis
- persistent inflammatory focus (injury, necrotic tissues)
- shock
- SIRS
secondary causes of MODS
- age
- pre-existing conditions
- dysregulated apoptosis
optimizing respiratory issues of a pt with MODS
- mechanical ventilation
- elevate HOB
- decrease O2 needs
- tracheal suction as needed
- fluids on time
- ABX and Beat-adrenergics
optimizing tissue perfusion in MODS
- decrease anxiety
- calm, quiet environment
- inotropes
- vasoconstricting agents
- activated protein-C
HIV primary infection
symptoms are none to flulike
CDC category !
period of rapid viral replication and dissemination through the body
HIV asymptomatic
more than 500 CD$+ T cells
