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Drug Interaction > Agitation > Flashcards

Agitation Flashcards

1
Q

Carbamazepine

A 
Oral contraceptive
Lovastatin
Meperidine
Morphine
Nifedipine
Oxycodone
Trazodone
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2
Q

Divalproex

A

Lamotrigine

Lorazepam

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3
Q

Trazodone

A

Priapism

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4
Q

TCA

A

Anticholinergic effect
Monitoring require
ECG abnormalities (caution in patient with cardiovascular disease and arrhythmias)

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5
Q

Mirtazepine

A

Weight gain

Sedation

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6
Q

Maoi (phenelzine）

A

Edema

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7
Q

Lithium

A 
Interac with
NSAID
Ace
Arb
Thiazide diuretic 
Require stable salt and caffeine intake
S/E:
GI upset and polyuria
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8
Q

Atypical

A

Side effect
Extrapyramid ( reduce in 2nd generation) unless use as high dose
GI
Heart problems (stroke) ( on quetiapine, risperidone/olanzapine)
Weight gain ( issue for 2 nd generation )
-due to abnormality glucose
-hyperlipidemia ( clozapine and olanzapine) Cl with diabetes
-high triglyceride ( Quetiapine)

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9
Q

Ssri

A

S/e
GI cns
Sexual dysfunction

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10
Q

MAOI

A

Edema

Can induce hypertension

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11
Q

Divalproex

A 
Weight gain (antiepileptic)
Polycystic ovary syndrome 
Hyperammonemia
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12
Q

Clozapine (atypical)

A

Require regular blood monitor

Cardiovascular side effect

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13
Q

Antipsychotic ( 1 st generation)

A

NMS ( for 1 and 2nd generation ) cause muscle restless ( might damage the muscle)( autonomic dysfunction which is irregulars HR,etc)
Sedation and cognitive (problem with remembering認知障礙
( anticholingeric and anticonvulsant) worse the cognitive
TD ( dyskinesia) uncontrolled movement ( with initial treatment)
Cardiovascular problem
Endocrine and sexual problem
Hyperprolactinemia ( high prolactin ) like milk product when not pregnant
-Fertility problem
-Irregular menstrual

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14
Q

Clonazepam and diazepam

A

Long acting

Could use for switching from benzo withdrawal

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15
Q

Benzo

A

Short acting ( give greater risk of fall especially in elderly)
Better with the lorazepam for elderly
Flurazepam and nitrazepam ( give hangover)
Triazolam ( only help to fall asleep but not to maintenance the sleep and cause memory loss ( amnesia) not suitable for elderly )
Oxazepam (take 60-90 mins before slow absorption good for maintenance)
If use for long term( heart problem like hypertension or seizure might occur)

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16
Q

Zopliclone

A

Effect the taste

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17
Q

L-tryptophan

A

S/E:Serotonin syndrome

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18
Q

MAOI
Antidepressant (SSRI,SNRI,TCA)
Opioid

A

Could give s/c serontonin syndrome

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19
Q

Clonidine

A

Alpha adrenergic anoints
Treat for hypertension,ADHD,withdrawal symptoms from alcohol or opioid)
Can treat for smoking cessation for those who have hypertension ( anything that treat for heart can give hypotension as s/E)
CI with TCA.
Uncommon side effect: memory problem

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20
Q

Trazodone

A 
Antidepressant
Serotonin agonist
( can be use for insomnia)
Can use to lower BP and HR
S/E: priapism
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21
Q

Bupropion ( Wellbutrin /Zyban)

A

Noephirphine and dopamine reuptake inhibitor?
S/E:insomnia difficult concentrate
Eating disorder/ seizure

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22
Q

Buspirone

A

Azapirones
Switch for benzo
(Those couldn’t take benzo for the general anxiety disorder)

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23
Q

Pregabalin and gabapentin

A

Antiepileptic
S/E:unsteady gait(walk)
Edema
For not general seizure

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24
Q

Atomoxetine

A

Norepinephrine reuptake inhibitor

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25
Q

SSRI

A

Sexual dysfunction

GI and CNS effect

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26
Q

Thiamine

A

For alcohol withdrawal

Eating disorder to prevent wernick of

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27
Q

Ergotamine

A

Vasoconstriction

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28
Q

Tristan’s

A

Chest discomfort
Nasal formulation S/E: taste disturbance
Do not use if any cardiac symptoms\

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29
Q

Flunarizine ( CCB)

A

S/E:
Depression
EPS
Constipation

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30
Q

Phenytoin

A

Antiepileptic
Increase body hair
Gingival hyperplasia ( over growth of gum)

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31
Q

Antiemetic

A

EPS (Parkinson’s like symptoms )

CI:alcohol

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32
Q

Beta blocker

A

Depression

CI:antacid , contraindicate with pulmonary and cardiac disease

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33
Q

NSAID

A

CI: antihypertensive

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34
Q

Prednisone

A

CI：diabetes ,peptic ulcer

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35
Q

Quinine sulfate

A

Visual impaire ,fatal thrombocytopenia

36
Q

Dopamine agonists

A 
Daytime sleepiness (attack of sleep),heart problem
Personality change
37
Q

bromocriptine

A

Cardiac and Pulmonary fibrosis

38
Q

Pergolide

A

Cardiac valve fibrosis

39
Q

amantidine

A

Leg edema

40
Q

Antiepileptic

A 
Hypersensitive syndrome (monitor cbc and liver serum)
Watch out for blood and liver
41
Q

Iminostibene derivatives

A

Neutropenia
Hyponatremia
CI: contraceptive
May worse absence seizure

42
Q

Ethosuximide ( suinimide derivative)

A

For absence seizure only

43
Q

Vigabatrin

A

Vision problem

44
Q

Ciprofloxacin

A

Photosensitive

Abdominal pain

45
Q

Aminoglycoside (eye drop)

A

Conjunctivitis

46
Q

Carbonic anhydride inhibitor

brinzolamide>dorzolamide>acetazolamide and methazolamide

A

Should not use in patient with sulfonamide allergy

S/E: GI and CNS ,renal and paresthesia ( hand) mainly for acetazolamide and methazolamide ( for emergency use only)

47
Q

antihistamine

A

caution in glaucoma patient due to anticholingeric effect

48
Q

synthroid

A

interaction with iron supplement ( decrease absorption of T4)

49
Q

Sibutramine

A

Satiety enhancer
SNRI
Increase heart rate and BP

50
Q

Orlistat

A

Fecal urgency

CI ：decreased absorption of soluble vitamins （take 2 hrs apart）

51
Q

Rimonabant

A

Block CB-1 receptor
Endocannabonid system
Suppress food intake
S/E depression and n&v

52
Q

Statin

A

S/E:Muscle pain

Liver toxicity

53
Q

Niacin

A

Side effect flushing （red face）

Gout

54
Q

ACE

A

S/E: dry cough , angioedema (ARB)

55
Q

NSAID , corticosteroid,stimulant

A

Can indue hypertension

56
Q

Drink

A

9 per week for women

14 per week for men

57
Q

Beta blocker

A

Use for patient less than 60
Ineffective use as cardiovascular prevention for smoker
Avoid in sever peripheral arterial disease
Avoid in asthma patient
Taper the dose before D/C
S/E: depression, heart failure

58
Q

CCB
Diuretic
ARB

A

Use for patient over 60

59
Q

ACE

A

1st line for diabetes, history of MI, heart failure, kidney disease
Teratogenic for pregnancy ( ARB)
Not recommend as initial therapy for black people
S/E: dry cough
( drug that end with ‘’pril’’ like ramipril)
Treat patient with renal dysfunction

60
Q

Loop diuretic

A

Can use for renal impairment ( serum creatine greater than 150)

61
Q

Diabetes with nephropathy

A

Use ACE or ARB

62
Q

Heart failure

A

Avoid nondihydropyridine CCB ( diltiazem ,verapamil)

63
Q

Patient with bilateral or unilateral renal artery stenosis disease

A

Avoid ACE/ARB

64
Q

Diuretic

A

S/E: hypotension,hypokalemia, muscle cramp

Ineffective in those with ClCr less than 30

65
Q

Metolazone

A

Diuretic ( effective in moderate to sever renal dysfunction)

66
Q

Beta blocker nonselective

A

Nadolol
Timolol
Propranlol

67
Q

Beta blocker selective B1

A

Metoprolol
Atenolol
Bisoprolol

68
Q

Beta blocker with aplpha blocking activity

A

Labetalol

S/E: edema

69
Q

ARB

A

Drug end with ‘’sartan’’ like candesartan
Cause Renal dysfunction an hyperkalemia （same as ACE)
Require close monitoring of creatine,potassium

70
Q

CCB( dihydropyridine)

A

Edema

Not recommend for STEMI patient

71
Q

Cholesterol greater than 3.5

A

Treat with statin therapy

72
Q

Ticlopidine

A

Antiplalet

( last choice) a lot of S/E :neutropenia ,thrombocytopenia,thrombotic

73
Q

Nitrate

A

S/E: headache,syncope ( faint) there for sit when taking the sublingual tab

74
Q

Levocabastin

A

Nasal antihistamine

75
Q

Ipratropium ( atrovent)

A

Antimuscarine short acting
Broncho Muscle dilation and decrease mucus secretion
Treat for COPD / running nose

76
Q

Oxybutin

A

Selective M3 receptor

Primary receptor in bladder ( help to hold the bladder for urine）

77
Q

SABA ( fenoterol,salbutamol,terbutaline)

A

S/E: tachycardia,palpitations

High dose may lead to hypokalemia and tremor

78
Q

Singular

A

S/E: headache

79
Q

Theophylline

A

Serum level should be measure ( between 55-85)
Drug level increase if patient stop smoking
S/E:Abdominal cramps

80
Q

Ketotifen

A

Adjunctive anti-inflammatory

81
Q

Tetracycline

A

Cyclin ( think about the bicycle ）
Contraception pills become less effective
Also empty stomach and 30 min sit after taking, no calcium

82
Q

Oxygen (55-59)

A

Give oxygen therapy ….resting oxygen should be 65-80

83
Q

Cephalosporin

A

S/E: GI intolenrance

84
Q

Metronidazole

A

Steven Johnson syndrome ( red skin and peeling)

Taste and urine discolour

85
Q

Sulfonamide ( stop folic acid synthesis) sun,high urin ( very dry) so drink a lot of water and folic acid daily
Tetracycline ( stop protein synthesis)
Fluroquinolone ( for UTI and peunomia)

A
86
Q

Beta blocker

A

Use for general all patient with NSTEMI

87
Q

Potassium sparing

A

Don’t use if creatine serum greater than 221
Potassium greater than 5
Creatine clearance less than 30

Drug Interaction (1 decks)

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