Aging Skin

Question 1

Problems of aging skin

Answer 1

dryness, fine lines and wrinkles, age spots, and skin cancer

Question 2

How do cells respond to excessive UV damage?

Answer 2

Activation of transcription factors NF-kappaB, AP-1, p53

Question 3

Direct absorption of UVB photons leads to

Answer 3

dimerization of pyrimidine bases, replication of damaged DNA

Question 4

Absorption of UVA leads to

Answer 4

G –> T transversions and oxidative damage

Question 5

What is the p53 gene?

Answer 5

• regulates cycle progression by arresting in late G1 or triggers apoptosis
• most commonly mutated gene found in human cancers
• the last gatekeeper from normal cell to tumor