Aggression & CD Flashcards

1
Q

Antagonism is an ancient construct with aggression dating back centuries to the days our ancestors

A

displayed violence to establish control, an act they considered as assertion of dominance and power

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Aggressive outbursts can happen suddenly

A

as an emotional reaction to frustration or upset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

However, sustained aggression and antisocial behaviour is cause for concern

A

and can be observed during every stage of human development, from early childhoof through to adult life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Aggressive behaviours are rather universal in young children

A

though as they grow older most children tend to socialise and learn to inhibit these aggressive behaviours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The key mechanisms involved in this process of socialisation are

A

> development of cognitive control of impulses
sensitivity to feedback in particular punishment through conditioning
development of empathy
sense of morality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Some children, however, fail to follow this path of socialisation and continue manifesting

A

aggressive and rule-breaking behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

These children may fall within the categories of psychiatric disturbance behaviour disorder

A

of which the most severe is conduct disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

According to DSM-, CD is defined as the repetitive and persistent pattern of antisocial behaviour in children

A

associated in particular with violation of social norms and basic rights of others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Early onset CD can be recognised in children as young as 5 years of age

A

with diagnosis commonly confirmed between ages of ten to nineteen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

To qualify for CD diagnosis

A

deliquent behaviour must be sustained lasting for a period of over six months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Specific criteria for CD diagnosis including

A

aggression towards humans and animals
deceitfulness or theft
destruction of property
serious violation of authority

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

the mechanisms underlying development and progression of such behaviours

A

include several factors, both biological and environmental

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

development of conduct problems in children can be largely attributed to the environment in which a child has been brought up in

A

with evidence of certain prenetal factors including smoking and consumption of alcohol shown to have a strong negative impact on the development of CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Exposure of children to negative experiences such as trauma, violence and neglect

A

during their early years can have drastic consequences on their day to day behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Youths diagnosed with such conditions have often not received the level of care and prosocial behaviour that innocent children deserve

A

instead these individuals have often been subjected to parental rejection, substance abuse or antisocial behaviour at home, leaving children to fend for themselves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

They feel as if the world is out to get them

A

and rightly so with the unfortunate circumstances they have been through

17
Q

It can be said therefore that a lack of prosocial behaviour

A

can lead to antisocial traits

18
Q

Early life stress is a large contributor in the development of CD

A

with aggressive behaviour shown to increase with heightened stress levels

19
Q

Several animal studies have provided valuable insights into the effects of early stress of development of aggression

A

whereby separation of young male rats from their mothers has been shown to increase aggressive behaviour

20
Q

Children raised in stressful situations are left feeling constantly threatened therefore

A

leading to unregulated emotional responses and frustration based reactive aggression

21
Q

So while there should be no excuse for antisocial behaviour

A

in cases of CD, there often is an environmental explanation for it

22
Q

Furthermore, studies linking ADHD presentations including inattention, impulsivitity and hyperactivity

A

to conduct problems propose a causal link, suggesting that those with ADHD may be at a higher risk of CD development (Aggressotype consortium, 2013 - 2018)

23
Q

Genetic mechanisms of CD

A

5-HTT gene SLC6A4
COMT
MAOA

24
Q

The MATRICS project (2013 - 2019)

A

sought to further understand the neural, genetic and epigenetic mechanisms underlying these psychiatric disruptive behaviour disorders, notably ODD and CD

25
The aim of the project therefore was to identify the factors involved in pathogenesis of aggression and antisocial behaviour in distinct populations
normally developing adolescents those at high risk (ADHD) children and adolescents with CD
26
To identify these factors, the project adopted
a translational approach of matching preclinical studies on animals to clinical studies by basing them on identical paradigms and methodology
27
This allowed for optimal cross-validation of findings from
animal models to humans, and vice versa
28
The BALB/cJ mouse model utilised within the MATRICS study has
provided valuable insights into the mechanisms underlying aggressive behaviour
29
These mice display an aggressive and antisocial phenotype
accompanied by high anxiety, inattention and reversal learning deficits
30
In vivo MRI identified loss of inhibitory GABAergic cingulate cortical control mechanisms in the mouse model
with phenotypic remediation by methylphenidate and oxytocin through fear processing and empathy regulation, respectively
31
Furthermore, the potential role of opioid signalling and RBFOX1 methylation
as key regulators of the aggressive phenotyped were identified through whole genome sequencing analysis
32
Regulation of salience networks by
feedback approaches in human CD may be useful
33
as well as targeting immune-related attentional mechanisms
which appear to be causal to the aggressive phenotype in multiple ODD/CD and population cohorts (MATRICS consortium, 2013 - 2019)