Agglomeration processes. Part 2: Wet granulation

Question 1

What are the benefits of using fewer excipients?

Answer 1

Good homogenity and flow properties

Question 2

Give examples of liquid phase excipients?

Answer 2

binder and solvent

Question 3

What are 3 main forces between particles?

Answer 3

surface tension
solid bridges between particles
capillary vacuum

Question 4

What is sintering?

Answer 4

Sintering is a manufacturing process in which powdered materials are compacted and then heated below their melting point to fuse the particles together into a solid mass

Question 5

How does intragranural moisture content affect pharmaceutical products?

Answer 5

In pharmaceutical manufacturing, the intragranular moisture content affects the stability, shelf life, and physical properties of granulated drugs or powders.
Excessive intragranular moisture can lead to degradation or spoilage, while insufficient moisture may make granules too brittle or affect drug release profiles.

Question 6

What is consolidation?

Answer 6

vandens sumazejimas del pressure medziagoje

Question 7

What is collision?

Answer 7

Collision= where they collide and exchange energy.

Question 8

What does wet granulation equipment consists of?

Answer 8

Main paddle stirrer
High-speed stirrer (chopping knife)

Question 9

Energy needed to form granules depends on the……..
is proportional to the ……..

Answer 9

…bulk density and flow properties of the bulk material
……reduction of the solid phase surface

Question 10

What does API stands for?

Answer 10

active pharmaceutical ingredient