Agents used to treat hyperlipedemias Flashcards
what is hyperlipidemia?
defect in lipid transport system that provides cholesterol and triglycerides to the cell
what does hyperlipidemia increase the risk of?
inc risk of coronary artery disease with increase in blood lipids
inc risk of plaque formation
inc risk of pancreatitis
inc risk of xanthoma
what do different levels of LDL cause?
160- 4x inc in coronary artery disease
what causes secondary hyperlipoproteinemias?
cirrhosis, nephrosis- alcohol and diabetes
drugs
what causes primary hyperlipoproteinemias?
genetic abnormalities- decrease lipoprotein lipase abnormal LDL receptors overproduction of VLDL decrease HDL synthesis
non-pharmacologic treatment of hyperlipidemias
weight loss
diet- decrease fat and cholesterol
stop smoking
aerobic exercise
pharmacologic treatment of hyperlipdemias
decrease production of lipoproteins
increase removal of lipoproteins
decrease absorption of lipoproteins
some of these agents may affect the fetus
what are the hypolipidemic agents?
HMG coA reductase inhibitors niacin bile acid binding resin fibrates omega 3 fatty acids and icosapent lomitapide mipomersen
what are the agents that decrease cholesterol absorption by the intestine?
ezetimibe
sitostanol
orlistat
olestra
what is the most effective LDL lowering agent?
HMG CoA reductase inhibitors
what causes the strongest increase of HDL?
Niacin
what is the best triglyceride lowering agents?
fibrates
what can bind to acidic drugs? acidic drug example?
bile acid binding resins
digoxin
what can displace warfarin from plasma binding sites?
the fibrates
what are the HMG CoA reductase inhibitors?
statins