Agents Flashcards
Which bacterial/rickettsial agents in infected animals are housed at ABSL2?
Bacillus anthracis - Infected rodents
Bordatella pertussis
Mycobacterium tuberculosis - Guinea pig and mouse studies
Salmonella typhi - Most animal studies
Yersinia pestis - Based on risk assessment
Rickettsia prowazekii, typhi, rickettsia - Mammals
Which bacterial/rickettsial agents in infected animals are housed in ABSL3?
Brucella species
Burkholderia mallei
Burkholderia pseudomallei
Chlamydia psittaci - Infected birds
Francisella tularensis
Mycobacterium tuberculosis - NHPs
Salmonella typhi - Animal studies with aerosols
Yersinia pestis - Based on risk assessment
Coxiella burnetti
Where do the remaining bacterial/rickettsial agents fall?
Less important, as they are BSL2 only, or are primarily human diseases.
Which of the listed bacterial/rickettsial agents are select agents? Select agents, Tier 1?
Select: Brucella, Coxiella burnetti, Rickettsia (only select that is BSL2)
Tier 1: Bacillus anthracis, Burkholderia mallei and pseudomallei, Francisella tularensis, Yersinia pestis
How is Mycobacterium leprae propagated?
In armadillos and footpads of mice.
Which ‘less important’ bacterial agents use BSL3 practices if aerosols are produced? If the compound is in high production/concentration?
Aerosol: Legionella, Neisseria gonorrhoeae or meningitides
High dose/concentration: Neisseria gonorrhoeae or meningitides
Which fungal agents are handled at BSL2?
Blastomyces dermatitidis
Coccidioides immitis, C. posadasii (some) - Parenteral
Cryptococcus neofromans
Histoplasma capsulatum
Sporothrix schenckii
Dermatophytes
Which fungal agents are handled at BSL3?
Coccidioides immitis and posadasii - Animals with intra-nasal or pulmonary routes
Which fungal agent is a select agent?
Coccidioides immitis
What toxins are select agents?
Staphylococcal enterotoxins, Ricin toxin
What toxins are select agents, Tier 1?
Clostridium botulinum toxin
Animal work with which viral agents is performed at ABSL4?
Hantavirus - Permissive rodent species
Hendra/Nipah virus
B virus - Experimental infections of rodents and macaques
Smallpox
Animal work with which viral agents is performed at ABSL3?
Influenza - Wild type human strains, 1918 strain, HPAI
LCMV - Hamsters
Monkeypox - Experimentally or naturally infected
SARS
West Nile
EEE, VEE, WEE
Rift Valley Fever
Animal work with which viral agents is performed at ABSL2?
Hantavirus - Experimentally infected rodents
Hepatitis B, C, and D - NHPs
Influenza - Circulating human strains, LPAI, equine and swine strains
LCMV - Adult mice with mouse brain-passaged strains
Rabies
HIV/SIV/Retroviruses
Which viral agents are select agents?
Hendra, Nipah, B virus, HPAI, 1918 flu strain, Monkeypox, EEE, VEE, Rift Valley Fever, African Horse sickness, African swine fever, Congo-Crimean Hemorrhagic Fever, Lassa fever, Machupo
What viral agents are select agents, Tier 1?
Variola (smallpox), Ebola, Marburg
