Ageing Process Flashcards
1
Q
What is ageing?
A
Progressive, generalised impairment of function resulting in a loss of adaptive response to disease
2
Q
What is senescence?
A
Process by which a cell stops dividing and undergoes growth arrest without undergoing cell death
3
Q
What causes damage to macromolecules?
A
Ionising radiation
Reactive oxygen species (diet, radiation, inflammation)
Extrinsic toxins
4
Q
What are the 4 responses to damage accumulation?
A
Repair
Apoptosis
Sensecence
Malignant transformation
5
Q
What causes frailty?
A
Loss of homeostasis and resilience
Increased vulnerability to decompensation after a stressor event
6
Q
What are the 2 main models used for assessing frailty?
A
Rockwood (deficit accumulation) Fried score (phenotypic)
7
Q
Are multimorbidity and frailty the same?
A
NO
