Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 2.4 PONV etc > affective disorders > Flashcards

affective disorders Flashcards

You may prefer our related Brainscape-certified flashcards:
WSET ® Level 4 D2 Business of Wine flashcards
1
Q

describe tyramine toxicity

A

uptake of tyramine into the Adrenergic neuron via vmat into the synaptic vesicle where it displaces norepinephrine causing reverse transport of norepinephrine out of the neuron.

tyramine is an indirect sympathomimetic=HTN crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some adverse effects SSRIs- fluoxetine/Prozac escitalopram/Lexapro?

A

GI distress
sexual dysfunction
serotonin syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Locus coeruleus is a target for PTSD. What receptors?

A

Locus coeruleus is a target for PTSD. What receptors?
Prazosin-a1
Clonidine a2
Dexmedetomidine a2

Decrease noradrenergic neurotransmission.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

all loose tigers are dangerous, send signal of fear renewal/adaptive to amygdala

A

prelimbic cortex/prefrontal cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

herb, used for treating depression, downregulation of beta receptors in the brain, probably increases norepinephrine, upregulate CYP enzymes, may cause photo sensitivity and neurotoxicity

A

Saint Johns wort

can also interact with prescription antidepressants and other drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

name two selective serotonin reuptake inhibitors

A

fluoxetine/Prozac

escitalopram/Lexapro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name two tricyclic antidepressant

A

Amitriptyline/Elavil

Desipramine/norpramin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse effects include-block sodium channels in the heart in the CNS which can lead to lethal conduction delays and seizures?

A

TCA
Amitriptyline/Elavil
Desipramine/norpramin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Define affective disorder.

A

profound emotions without the appropriate situational context.
major depressive order
anxiety slash panic disorder
post-traumatic stress disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

First line treatment for major depression and anxiety, very selective, decrease side effects

A

ssri
fluoxetine/Prozac
escitalopram/Lexapro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

why don’t you mix SSRI MAOI and triptan(5HT agonist)

A

Serotonin syndrome-dangerous elevations in serotonin levels or serotonin neurotransmission causes hyperthermia muscle rigidity myoclonus and rapid fluctuations in vital signs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which MAO metabolizes dopamine?

A

MAO B for brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Serotonin-norepinephrine reuptake inhibitor

A

Cymbalta/duloxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Used to treat patients that don’t respond to SSRI, also used to treat fibromyalgia, chronic neuropathic pain, and hot flashes

A

serotonin norepinephrine reuptake inhibitor

Cymbalta/duloxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Major depressive disorder is likely due to decreased_______ and__________ while PTSD is likely due to increased________ and _______ with decreased ________.

A

major depressive disorder is likely due to decreased dopamine and norepinephrine
PTSD is likely due to increased norepinephrine and glutamate with decreased serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How would you manage a TCA overdose

5

A 
Acls
Volume resuscitation
treat the seizure
treat cardiac arrhythmias with lidocaine
and some bicarb because TCAs are weak bases
17
Q

Blocks endocannaboid reuptake

A

Tylenol

18
Q

Selective irreversible Mao B inhibiter used to treat Parkinson?

A

Selegiline(eldepryl)

19
Q

CB1 receptor agonist, adjunct analgesics for neuropathic pain, anti emetic, appetite stimulant

A

Dronabinol/Marinol

Nabilone/cesamet

20
Q

MAO-A is responsible for the metabolism of what?

3

A

Tyramine, serotonin, norepinephrine

21
Q

name an A typical antidepressant

A

bupropion/Wellbutrin

22
Q

Selective MAO A inhibitor, reversible, hops on and off enzyme

A

Moclobemide (amira, auroix, clobemix)

23
Q

How does Wellbutrin/ bupropion work?

A

Wellbutrin/ bupropion
atypical
increases dopamine and serotonin extracellular levels by blocking transport DAT/SERT which displaces neurotransmitter from the nerve terminal

24
Q

Management of affective disorders. Increases NE, 5HT in neurons and vesicles. Increases tyramine concentration in blood, MAO-I –non selective, irreversible inhibitor

A

Phenlizine/nardil

25
Q

Phenlizine/nardil, iproniazid/marsilid, iprazid, ipronid are _______ _______ _____ _____ associated with tyramine toxicity

A

MAO-I –non selective, irreversible inhibitors

26
Q

an adverse effect of tyramine toxicity

A

Phenlizine/nardil

27
Q

these two drugs’ Adverse effects include blocking muscarinic receptors, histamine receptors and adrenergic receptors.

What signs and symptoms would blocking those receptors lead to

A

TCA
Amitriptyline/Elavil
Desipramine/norpramin

Muscarinic-dry mouth, blurred vision, confusion, tachycardia, urinary retention,

Histamine-sedation and confusion

Andrenergic-orthostatic hypotension, reflects tachycardia dizziness,

28
Q

How do monoamine oxidase inhibitors work as antidepressants?

A

Increase norepinephrine and serotonin via increased plasma tyramine

29
Q

Block norepinephrine and serotonin reuptake can also be used to treat chronic neuropathic pain, migraine, fatigue syndrome, not selective for transporters

A

TCA
Amitriptyline/Elavil
Desipramine/norpramin

30
Q

can be used to treat PTSD insomnia, nightmares, and reduce daytime flashbacks

A

Dronabinol/Marinol

Nabilone/cesamet

31
Q

How do TCA, SSRI, SNRI treat chronic pain?

A

Increase norepinephrine and serotonin neurotransmission in the dorsal horn

32
Q

caged tigers are not dangerous, sends signal to amygdala to suppress expression of fear in a no longer dangerous situation

A

infralimbic cortex/prefrontal cortex

Pharm 2.4 PONV etc (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions