Aerosols

Question 1

Define aerosol

Answer 1

a dispersion of solid or liquid particles (typically <50 µm diameter) in a gas (propellent)

Question 2

Critical part of aerosols

Answer 2

The particle size of the dispersed phase can be critical for the proper deposition of drug in the lung.

Question 3

Aerosol Advantages

Answer 3

directly administered to the affected area
rapid onset of therapeutic effect
dosage regulated/metered
single dose – no contamination (sterility)
sensitive materials protected
irritation minimized or eliminated
alternate route of administration (fewer side effects).
convenient and easy to use

Question 4

Aerosol limitations

Answer 4

variability of the bioavailable dose of the drug (coordination and penetration problems);
reduced duration of therapeutic effects (lung  very efficient clearance);
reduced aqueous solubility of drugs ( local irritation/inflammation);
low intracellular penetration of drugs (for treatment of cytosolic pathogens).

Question 5

Types of aeroli