Aerie Flashcards
The first FDA-approved medication in its class to lower elevated eye pressure in patients with open-angle glaucoma and ocular hypertension
Rhopressa
Rhopressa Active Ingredient
Netarsudil
Rhopressa provides consistent eye pressure reduction by supressing the _____ _______.
ROCK enzymes
MOST Study
Rhopressa provided consistent, additional IOP reduction regardless of the patient’s current regimen by providing patients with an additional 4mmHG in IOP reduction whether added to monotherapy or combination therapy.
MOA of ROCK Inhibitors
Work to relax the Trabecular Meshwork to improve aqueous humor outflow, which reduces pressure and also decreases EVP
The number 1 side effect for Rhopressa is ________, which effects roughly ___% of patients
Hyperemia; 53%
In __ / 10 Rhopressa patients overall, hyperemia was either not reported or graded as mild
9/10
Discontinuation rate for Rhopressa due to Hyperemia
6%
T/F There are no labeled contraindications for Rhopressa
True
Dosing regimen for Rhopressa / Rocklatan
Patients will administer one drop in the affected eye every evening
“One Drop Addition”
Rhopressa
Rhopressa Simple Call to Action
Make Rhopressa your 1st add to a PGA and gen an additional >4 mmHg IOP reduction
A unique, once-daily eye drop that helps reduce eye pressure through two different pathways.
Rocklatan
First and only fixed-dose combination in the US that combines 2 compounds with true 24-hour dosing within the simplicity of a single bottle
Rocklatan
The ____ and _____ inhibitors of Rocklatan provide patients with superior efficacy vs its individual components at all time points in Phase 3 clinical trials
PGA and ROCK
Rocklatan Active Ingredients
Netarsudil
Latanaprost
Rocklatan vs Latanoprost Clinical Trials
Nearly twice as many Rocklatan patients achieved a 30% IOP reduction
3x as many Rocklatan patients achieved an IOP reduction of 40% or more vs latanoprost
Nearly 60% of Rocklatan patients achieved an IOP reduction of roughly 16mmHg (compared to only 37% of latanoprost patients)
Rocklatan maintained ________ over its individual components in the 12-month study
Superiority
Most common side effect for Rocklatan is _______ and affects about __% of patients
Hyperemia; 59%
For __% of those Rocklatan patients who experienced hyperemia, it was mild and the severity did not increase over time
90%
Only __% of Rocklatan patients discontinued treatment due to hyperemia
5%
Rocklatan Simple Call to Action
Replace latanoprost with Rocklatan for proven superiority and achieve target IOP with simplified dosing
Rhopressa is for patients who: (3)
Need 4 mmHg of IOP reduction regardless of baseline
Need consistent IOP reduction when adding a medication
Can’t take a beta blocker or alpha agonist due to contraindications
Rocklatan for patients who: (4)
Need lower IOP when a PGA isn’t enough
Achieving target IOP in a single bottle is important
Want to minimize the number of drops and bottles for simplicity
Want to reduce their number of copays
“The One Drop Difference”
Rocklatan
Rhopressa and Rocklatan Copay offer
Most of those commercially insured and covered patients will pay as little as $25
