AEDs Flashcards
List 3 side effects of phenytoin
- gingival hyperplasia
- bone demineralisation
- steven johnson
- diziness
- ataxia
- headaches
- nystagmus
How are phenytoin levels monitored
- salivary levels
What are contraindications and interactions of phenytoin?
CI: antidepressants, COCP
I: CYP inducer: induced COCP, NSAIDs, steroids. ALso protein bound: NSAIDs, valpoate
Give 3 side effects of carbemazepine
- bone marrow surpression
- dizziness
- ataxia
- drowsy
= motor distrubance - numbness
- neutropenia
- low Na
- SJS
What monitoring is needed for carbemazepine?
- plasma conc after 1-2 weeks
- manufacter advices fbc, u&e, lft but little evidence for benefit
What interactions and CIs are there for carbemazepine?
CI: antidepressant and COCP, AV conduction problems
I: CYP inducer, also induces itself
What side effects are common with lamotrigine? What interaction does it have with COCP?
- less ataxia and diziness
- N+v
- SJS
- NOT A CYP INDUCER
- COCP decreases its effect
What monitoring is needed for sodium valproate?
- salivary levels
- LFTs
- very teratogenic so ensure not pregnant
- can cause weight gain but doesnt need specific monitoring
- inhibited by antidepressants and antagonised by antipsychotics
- protein bound
What side effects can you get from levetiracetam?
- depression
- behaviour issue
- sedation
- dizziness
- ataxia
- no interactions or monitoring required
Give 4 side effects of levo dopa
- dry mouth, constipation
- REM sleep disorder
- dizziness
- hallucinations and delusions
- impulse control disorder (gambling, binge eating, hypersexual)
- decreased efficacy over time
- fluctation and freezing after 10 yrs or so
Give 2 side effects of MOAB inhibitors (rasigilline)
- postural hypotension
- AF
- no dopaminergic side effects (drowsy, n+v, impulse control disoder, psychosis)
