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CV Pharm > Adverse reactions > Flashcards

Adverse reactions Flashcards

1
Q

Terazosin

A

orthostatic hypotension (first dose), sinus tach (angina, palpitations), syncope, vertigo

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2
Q

Prazosin

A

First dose orthostatic hypotension, sinus tach (angina, palp.), syncope, vertigo

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3
Q

Phentolamine

A

Postural hypotension, reflex tachycardia (can lead to arrhythmias)

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4
Q

Phenoxybenzamine

A

Sinus tach, nasal congestion, drowsiness, fatigue, weakness, malaise, confusion, headache, xerostomia, ejaculation dysfunction

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5
Q

Beta blockers

A

CHF, bradycardia, bradyarrhythmias, cold extremities, tachyarrythmia with abrupt stopping of drug, bronchospasm for non-selective ones esp., CNS depression if lipophilic (mental disorders, fatigue, vivid dreams), increased TG, decreased HDL, delayed recovery from hypoglycemia in T1 diabetics, decreased exercise tolerance, fatigue

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6
Q

Ganglionic blockers

A

Postural hypotension, tachycardia, arrhythmias, blurred vision, double vision, asthma (2º to histamine release), dry mouth, constipation, paralytic ileus, N/V, urinary retention, impotence, drowsiness, seizures, hallucinations, tremor, confusion, neuromuscular blockade

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7
Q

Clonidine

A

Somnolence, dry mouth, abdom. pain, constipation, hypotension, sinus bradycardia, decreased libido, impotence, pregnancy cat. C

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8
Q

Methyldopa

A

Messes with catecholamine quantitation, sedation, sleep disturbances, erectile dysfunction, NA/water retention, lactation, positive Coombs

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9
Q

Reserpine

A

Sedation, inability to concentrate/perform complex tasks, suicidal tendencies, teratogenic

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10
Q

Procaineamide

A

Drug induced lupus, torsade de pointes

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11
Q

Lidocaine

A

CNS: agitation, confusion, seizures

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12
Q

Amiodarone

A

Pulmonary fibrosis, gray-blue skin (photosensitivity dermatitis), corneal halos, optic neuritis, hypo/hyperthyroidism, proximal muscle weakness, hepatitis

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13
Q

Sotolol

A

Torsade de pointes

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14
Q

Ibutilide

A

Torsade, transient asystole

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15
Q

Verapamil

A

SA/AV block, impaired contractility, hypotension, sinus bradycardia or AV block in people with CHF or LV dysfunction

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16
Q

Digoxin

A

Any kind of arrhythmia (ventricular bigeminy is specific), DADs, visual changes (yellow-green halo), headache, fatigue, drowsiness, confusion, seizures

17
Q

Adenosine

A

Chest tightness, transient asystole, flushing

18
Q

Epinephrine

A

Cerebral hemorrhage (esp with non-specific BBs), ventricular arrhythmias, angina

19
Q

Norepinephrine

A

Cerebral hemorrhage (esp with non-specific BBs), ventricular arrythmias, angina, bigger increase in BP than epi

20
Q

Dopamine

A

at high doses, increased peripheral vasc. resist. and renal vasoconstriction

21
Q

Ephedrine

A

angina, ventricular dysfunction, palpitations, V tach, fatal arrhythmias (including Vfib)

22
Q

Statins

A

Mild transient GI distress, increased liver enzymes, sleep disturbance, reduced daytime vigilance, memory loss, teratogen, myalgia, myositis, rhabdomyolysis

23
Q

Bile acid sequestrants

A

GI: bloating, nausea, flatulence, constipation, fecal impaction, hypertriglyceridemia

24
Q

Ezetimibe

A

Fatigue, abdominal pain, diarrhea, arthralgias, back pain, liver enzyme elev. (discontinue drug if >3X normal value)

25
Q

Fibrates

A

gastroesophageal reflux, diarrhea, increased liver enzymes, gallstones, teratogen

26
Q

Fenofibrate

A

Increased creatinine (reversible)

27
Q

Niacin

A

Cutaneous flushing, elevated liver enzymes, hepatic failure, hepatitis, GI irritation (nausea), hyperuricemia, gout, conjuctivitis, cystoid macular edema, retinal detachment, myositis (rare), dry skin, pruritis, icthyosis, acanthosis nigricans, insuline resistance (glucose intolerance, hyperglycemia)

28
Q

ACE inhibitors

A

Hypotension, azotemia, cough, angioedema, metallic taste in mouth, hyperkalemia, teratogen

29
Q

Diuretics

A

Electrolyte imbalances, hyperchloremic metabolic alkalosis, azotemia, dehydration, hypotension, tinnitus, hearing loss (loops)

30
Q

Nitroglycerine

A

Hypotension (high dose effect), dizziness, orthostatic hypotension, syncope, headache, drug rash

31
Q

Dihydropyridine CCBs

A

Excessive vasodilation: dizziness, hypotension, headache, GI: nausea, Edema, coronary steal (worse angina), reflex tachycardia, constipation

32
Q

Non-hydrypyridines

A

Bradycardia, asystole, AV block

33
Q

Ranolazine

A

Dizziness, headache, constipation, nausea, small reversible elev. in serum creatinine and BUN, syncope, asthenia

34
Q

ARBs

A

Hypotension, hyperkalemia, hepatic dysfunction (losartan), teratogen

35
Q

Minoxidil

A

hersutism, elevated renin

36
Q

Nitroprusside

A

excessive hypotension, tachycardia, palpitations, cyanide poisoning

37
Q

Atropine

A

Atropine blush

CV Pharm (1 decks)

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