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Pharmcology > Adverse Reactions > Flashcards

Adverse Reactions Flashcards

1
Q

Steven-Johnson’s Syndrome

A

Fever, sore throat, fatigue, wide spread flat blistering.

Antibiotics (co-trimoxazole, penicillin, trimethoprim), lamotrigine, phenytoin

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2
Q

Toxic Epidermal Necrolysis

A

Large peeling blisters

Antibiotics, NSAIDs, allopurinol, corticosteroids, anticonvulsants, methotrexate

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3
Q

Erythema multiforme

A

Raised target lesions

Antibiotics, anticonvulsants, allopurinol, aspirin

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4
Q

Extrapyramidal symptoms

A

Dyskinesia, akinesia, dystonia

Typical antipsychotics: haloperidol, chlorpromazine
Antiemetic: metoclopramide

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5
Q

Hyperprolactinemia

A

Gynaecomastia, galactorrea, loss of libido, amenorrhea

Atypical antipsychotics: olanzapine, risperidone
Typical antipsychotics: chlorpromazine
Antiemetics: metoclopramide
a-Methyldopa

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6
Q

Neuroleptic Malignant Syndrome

A

Fever, confusion, sweating, rigidity, autonomic dysfunction

Typical antipsychotics: haloperidol, chlorpromazine
Atypical antipsychotic: clozapine, olanzapine, risperidone, quetiapine
Antiemetic: metoclopramide

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7
Q

Serotonin Syndrome

A

Cognitive: headaches, confusion, coma
Autonomic: sweating, hyperthermia, tachycardia
Somatic: hyperreflexia, myoclonus, tremor

SSRIs: fluoxetine, citalopram
MAOi: selegiline, moclobemide
TCA: amitriptyline

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8
Q

Reye’s syndrome

A

Progressive encephalopathy: vomiting, confusion, loss of consciousness

Aspirin use in children
Also post chickenpox and influenza

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9
Q

Angioedema

A

Swelling around the mouth

ACEi

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10
Q

Rhabdomylsis

A

Muscle aches, myoglobinuria, acute renal failure

Statins

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11
Q

Nephtotoxicity

A

Acute renal failure

ACEi
Antibiotics: aminoglycosides

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12
Q

Lactic acidosis

A

Metformin

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13
Q

Orange urine

A

Rifampicin

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14
Q

Thyroid dysfunction

A

Lithium

Amiodarone

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15
Q

Aplastic anaemia

A

Antibiotics: chloramphenicol

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16
Q

Peripheral neuropathy

A

Antibiotics: nitrofurantoin

17
Q

Sensorineural deafness

A

Antibiotics: gentamicin

18
Q

Dental staining in fetus

A

Antibiotics: tetracycline

19
Q

Fixed drug eruption

A

Coincides with drug ingestion, typical site (glans penis), hyperpigmentation with healing.
Paracetamol, tetracyclines, NSAIDs, benzodiazepines

Pharmcology (1 decks)

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