Adverse Reactions Flashcards by Eunice Leong

Allopurinol

Stevens-Johnsons Syndrome

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Carbamazepine

Stevens-Johnsons Syndrome

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Co-trimoxazole

Stevens-Johnsons Syndrome

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Aminoglycosides

Ototoxicity

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Loop diuretics (e.g. furosemide)

Ototoxicity

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Macrolides

Ototoxicity

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Amiodarone

Grey discoloration of the skin
Corneal microdeposits
Pulmonary toxicity
Corneal microdeposits
Phototoxicity
Liver disorder
Hyper/hypo thyroidism

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Antiepileptics

Risk of suicidal thoughts and behaviours

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Finasteride

Risk of suicidal thoughts and behaviours
Sexual dysfunction

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Opioids

Respiratory depression

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Benzodiazepines

Respiratory depression

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Beta blocker

Raynaud’s phenomenon

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Bisphosphonates

Osteonecrosis of the jaw or external auditory canal, atypical femoral fractures

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Chloroquine

Psychiatric reactions

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Clindamycin

Stevens-Johnsons Syndrome
Antibiotic-associated colitis - C. diff

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Clozapine

Agranulocytosis
Intestinal obstruction, faecal impaction, paralytic ileus
Myocarditis and cardiomyopathy

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Methotrexate

Mucositis
Pneumonitis
Neutropenia

Nitrofurantoin

Risk of pulmonary and hepatic adverse reactions

Phenytoin

Gingival hyperplasia, Stevens-Johnsons Syndrome

SGLT2 inhibitor (e.g. dapagliflozin)

Fournier’s gangrene (acute necrotic infection of the perineum)

Vancomycin

Agranulocytosis
Neutropenia
Skin reaction

Warfarin

Calciphylaxis - painful skin rash

DPP4 inhibitors (e.g. Alogliptin)

Stevens-Johnson Syndrome
Acute Pancreatitis

Zolpidem

Sleep related behaviours (e.g. sleepwalking)

Pioglitazone

Heart failure Bladder cancer Osteoporosis, bone fracture Increase risk of infection Weight gain

Levothyroxine

Angina Palpitation Weight loss

GLP 1 medications (semaglutide, dutaglutide)

Pancreatitis Weight loss Altered taste, nausea Rash, angioedema, urticaria

Carbimazole

Neutropenia Acute pancreatitis Congenital malformations

Prednisolone

Diabetes Osteoporosis Growth impairment Depression Anxiety Mood swings, Hallucinations Hypertension

SGLT2 inhibitor

DKA UTI, dehydration, fluid imbalance Fournier's gangrene Hypotension Dyslipidaemia Thrush Increase risk of lower limb amputation (Canagliflozin) Weight loss

Loop diuretic (furosemide)

Hypercalcaemia

Sulphonylureas

Weight gain Hypo Renal impairment Photosensitivity, allergic dermatitis Leukopenia, haemolytic anaemia

DPP4 inhibitor (-gliptins)

Nausea Vomiting GORD Gastritis Hepatic failure (vildagliptin, alogliptin) Acute pancreatitis (dark urine, jaundice) Back pain, arthropathy Cardiovascular events

ACE inhibitors

Dry cough Angiodema

Trimethoprim

Thrombocytopenia Rash Fever, Sore throat, Rash, Mouth ulcers Megaloblastic anaemia Hyperkalaemia Interstitial nephritis Bone marrow suppression (unexplained bruising) Respiratory infection

Quinolones

Muscle weakness, Joint pain, Swelling tendon Changes to mood New onset palpitations, SoB

Macrolides (e.g. clarithromycin)

Tooth discoloration Epistaxis Burping and dry mouth

Doxycycline

Intracranial hypertension Photosensitivity

Amoxicillin

Diarrhoea Nausea Tooth discoloration (for oral suspension)

Nitrofurantoin

Urine discolouration (yellow/brown) Pulmonary adverse drug reactions Unxplained haematological or neurological syndrome Hepatic reactions