Adverse psychiatric effects of antimicrobials

Question 1

Antimalarials-example mefloquine, chloroquine

Answer 1

Reports of secondary psychosis, depersonalization and antimicrobial or mania in individuals with no psychiatric history.

Question 2

Fluoroquinolones example ciprofloxacin, levofloxacin, ofloxacin, rufloxacin

Answer 2

Psychosis associated with ciprofloxacin, sudden onset depressive symptoms and suicidal ideation associated with levofloxacin plus trimethoprim-sulfamethoxazole or Lomefloxin

Question 3

Gentamicin

Answer 3

Ray reports of secondary psychosis

Question 4

isoniazid

Answer 4

Reports of secondary mania or psychosis

Question 5

Macrolide antibiotics

Answer 5

Case reports of catatonia with azithromycin, psychosis and dissociation reported with clarithromycin

Question 6

Rifampin or sulfonamide antibiotics

Answer 6

Reports of exacerbation of existing panic disorder, hallucinations really associated with trimethoprim-sulfamethoxazole