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PSA > Adverse Effects > Flashcards

Adverse Effects Flashcards

1
Q

Enzyme Inducers

PC BRAS

A

P henytoin
C arbimazole

B arbiturates
R ifampicin
A lcohol (chronic excess)
S ulfonylureas

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2
Q

Enzyme inhibitors

AO DEVICES

A

A llopurinol
O meprazole

D isulfuram
E rythromycin
V alproate
I soniazid
C iprofloxacin
E thanol (acute)
S ulfonamides
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3
Q

Surgical drugs to stop

I LACK OP

A

I nsulin

L ithium (1 d before)
A nticoag/platelets (~1 w before)
C OCP/HRT (4 W before)
K -sparing diuretics (day of)

O ral hypogylcaemics
P erindopril (and other ACE-i - day of)
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4
Q

How much fluid lost?

Increased HR or decreased BP/UO

A

500 ml

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5
Q

How much fluid lost?

Decreased UO + increased HR

A

1 l

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6
Q

How much fluid lost?

Decreased UO + increased HR + signs of shock

A

> 2 l

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7
Q

Causes of hyponatraemia

Hypovolaemic

A

Dehydration (D & V)
Addison’s
Diuretics

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8
Q

Causes of hyponatraemia

Euvolaemic

A

SIADH

Hypothyroidism

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9
Q

Causes of hyponatraemia

Hypoervolaemic

A 
Failure:
Heart
Renal
Liver (low albumin)
Thyroid
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10
Q

Causes of neutropenia

A

Viral infection
Clozapine
Carbimazole

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11
Q

Causes of hypokalaemia

DIRE

A 
D rugs (loop & thiazide)
I nadequate intake
R enal tubule acidosis
E ndocrine (Cushing's/Conn's)
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12
Q

Causes of hyperkalaemia

A

D rugs (K-sparing & ACE-i)
R enal failure
E ndocrine (Addison’s)
D KA

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13
Q

Causes of prerenal AKI

Increase in urea > increase in creatinine

A

Dehydration

Renal artery stenosis

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14
Q

Causes of intrarenal AKI

Increase in urea < increase in creatinine

Not palpable

INTRINSIC

A 
I schaemia
N ephrotoxic abx
T ablets (NSAIDs/ACE-i)
R adiological contrast
I njury (rhabdomyolysis)
N eg bi crystals (gout)
S yndromes (glomeruloneph)
I nflammation (vasculitis)
C holesterol emboli
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15
Q

Causes of postrenal AKI

Increase in urea < increase in creatinine

Palpable

A

Lumen (stone)
Wall (tumour, fibrosis)
External pressure (BPH, prostate ca, lymphadenopathy, aneurysm)

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16
Q

Drugs causing AKI

A 
ACE-i
NSAIDs
Gent
Vanc
Tetracyclines
17
Q

Drugs causing deranged LFTs

A

Hepatitis:
Paracetamol overdose
Statins
Rifampicin

Cholestasis:
Fluclox
Co-amox
Nitrofurantoin
Steroids
Sulfonylureas

PSA (1 decks)

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