ADVERSE EFFECTS

Question 1

Photosensitivity in a patient with antiHTA med.

Answer 1

HYDROCHLOROTHIAZIDE

Question 2

Exaggerated sunburn? - Photosensitivity

Answer 2

Doxycycline

Question 3

HTA–> thiazide_______AE?

Answer 3

Photosensitivity!

Question 4

Amlodipine____AE?

Answer 4

Fluid retention and Urticarial Rash (psoriatic)

Question 5

ACEI (IECA) _____AE?

Answer 5

Angioedema, Urticaria

Question 6

Hydralazine ____AE?

Answer 6

Drug-induced Lupus
+ antinuclear ab
+ anti-histone ab

Question 7

Adenosine____AE?

Answer 7

Bronchospasm
CI: COPD AND Asthma

Question 8

Digoxin toxicity

Answer 8

N/V, anorexia, confusion, visual disturbance, cardiac abnormalities.

Question 9

CBC
Dihydropyridine (DHP): Amlodipine and nifedipine
____AE

Answer 9

EDEMA!!!!!!

Question 10

STATIN___ AE

Answer 10

Statin-induced myopathy

Question 11

Amiodarone_____AE

Answer 11

Lung Toxicity_ Chronic Interstitial Pneumonitis

hypothiroidism (Measure TSH)

Question 12

Metformin____AE

Answer 12

Ac. Lactic

Ci: cardio/hepatic/renal dfx

Question 13

Spironolactona___AE

Answer 13

Gynecomastia

Question 14

Fluoroquinolones _____ AE
- Ciprofloxacine
- Levofloxacin
- Norfloxacin
- Mixofloxacin

Answer 14

TENDON RUPTURE IN KIDS!!!!!

Question 15

Hyperplasia Gngival….

Answer 15

FENITOINA!

Question 16

Tetraciclyne ____AE (Fetus)

Answer 16

Dental Staining and reduction of Bone growth!

Question 17

BACTRIM ____ AE (Fetus)

Answer 17

Hyperbilirrubinemia and Kernicterus

Question 18

Medroxiprogesterone___ AE

Answer 18

brest tendernes
WEIGHT GAIN!!!
fatigue

Question 19

Valproate___AE

Answer 19

Neural tube defect…
(Pt. should continue the medication anyway!)

–> OR SWITCH TO LAMOTRIGINE!

__
Tmb
Elevated aminotransferase
Hepatic failure

Question 20

Progresive Sensory loss in distal, symmetric stocking-glove? EA___?

Answer 20

Metronidazole

Question 21

Long-term ( > 5 years) Metformin__AE?

Answer 21

Vit B12 deficiency
- megaloblastic anemia
- neurological findings

Question 22

Phenytoin toxicity

Answer 22

Horizontal nistagmus, ataxia, N/V
altered mental status

Question 23

Amitriptyline__AE?

Answer 23

Orthostatic hTA
Lethargy
Anticholinergic symptoms

Question 24

Hallucinations in Parkinson___

Answer 24

Dopamine +
(Levodopa)

Question 25

CMZ___AE?

Answer 25

N/V leukopenia

Question 26

Aminoglycocides ___AE?

Answer 26

Ototoxicity ..... sensorineural hearing loss Vestibular system .... imbalance

Question 27

Venlafaxine __AE?

Answer 27

HTA ... dose-dependant!!

Question 28

Akathisia...

Answer 28

Antipsychotics

Question 29

Lithium ___AE?

Answer 29

hypothyroidism HYPERPARATHIROIDIS w/ HYPER CA+ Nephrogenic DI CKD Teratogenic effects

Question 30

IMAO (Phenelzine) + Foods rich in Tyramine

Answer 30

HYPERTENSIVE CRISIS!!!!!!

Question 31

BBloquers___AE?

Answer 31

Weight Gain

Question 32

Dihydropyridine calcium channel blockers ___ AE? - Amlodipina...

Answer 32

EDEMA!

Question 33

IECA ____ AE?

Answer 33

Angioedema

Question 34

Aldosterone Agonist - Spironolactona - Eplerrenona

Answer 34

HYPER K+

Question 35

... changes in color vision...?

Answer 35

DIGOXINE toxicity

Question 36

Antracilcyne (Doxorrubicine) Trastuzumab

Answer 36

CArdiotoxicity

Question 37

STATINS ____ AE??

Answer 37

MUSCLE -- statin myopathy LIVER TOXICITY!!! - hepatitis

Question 38

Procainamide Hydralazine

Answer 38

DILE Drug-induced Lupus

Question 39

Sotalol....

Answer 39

Torsada de POintes (TdP)

Question 40

Methyltestosterone... AE?

Answer 40

acne

Question 41

Thiazolidinodionas (Pioglitazone)

Answer 41

Edema and Weight Gain

Question 42

Metformin___ AE?

Answer 42

LActic acidosis. (DO Not give in renal insuficiency)

Question 43

Sulfonylureas (Glyburide_Glimepiride)

Answer 43

hypoglycemia !!

Question 44

Glifozin SGLT-2. ___AE?

Answer 44

Decrease blood pressure! URINARY TRACT INFECTIONS!!!!!!!!!!!!!

Question 45

Lipodystrophy

Answer 45

HAART (Zidovudine)

Question 46

Bifosfonates

Answer 46

Osteonecrosis of the jaw

Question 47

FIBRATES - Gemfibrozil

Answer 47

Gallstone formation!

Question 48

Warfarin .. inhibits proteins S and C

Answer 48

Skin Necrosis!

Question 49

Heparin-induced....

Answer 49

Thrombocytopenia... Switch to Argatroban!

Question 50

AE Chemotherapy -Vincristine -Bleomycin -Doxorubicin - Cyclophosphamide

Answer 50

AE Chemotherapy -Vincristine --> Neurotox -Bleomycin. -->Pulmonary fibrosis and Skin decoloration -Doxorubicin --> CHF - Cyclophosphamide --> Hemorrhagic cystitis

Question 51

Acyclovir IV

Answer 51

Crystalline Nephropathy

Question 52

Amphotericin B

Answer 52

*** hypoK+ ***hypoMg+ *** Nephrotoxicity

Question 53

Acute Nitrofurantoin -induced pulmonary injury

Answer 53

Nitrofurantoine