Adverse Drug Reactions Flashcards
Questions for the ADR lecture
how many people on drug/placebo get ADR?
5%
how many people on drug/placebo get ADR?
5%
what is an adverse drug event?
bad thing during/following drug therapy
what is an adverse drug reaction?
adverse drug event due to a drug, determined by causality assessment
what is accutane (isotretinoin)?
acne drug
what is tegretol (carbamazepine)?
anti-epileptic
what is dilantin (phenytoin)?
anti-epileptic
ticlid (ticlopidine)
platelet inhibitor
zovirax (acyclovir)
antiviral
what are warning signs of acyclovir use?
hives, diff breathing, face swelling, lips, tongue, throat
what is a “type a” rxn?
augmented, what you would expect, dose related
what is a “type b” rxn
bizarre, off target, idiosyncratic, unexpected.
what is an example of a type a rxn?
digitalis
what is an example of a type b rxn?
phenytoin - anticonvulsant hypersensitivity syndrome - fever, rash, hepatitis, nephritis
SAFER MD?
Side Effects Alternative treatments Forfeit of treatment Expected benefit Regimen
Monitoring tests/visits
Duration of therapy
What is a “high risk drug”?
Small Tx window, DDIs
What are the 4 anti’s?
Anti convulsants, biotics, coagulants, inflammatories
What is a “high risk patient?”
Contrindications, warnings, age, general health, genetics
High risk situation?
Drugs aren’t necessary, too many drugs, patient not competent
What are contraindications for ticlid (ticlopidine)?
Hypersensitivity, bleeding problem, blood disorder, liver impairment.
What are contraindications for ticlid (ticlopidine)?
Hypersensitivity, bleeding problem, blood disorder, liver impairment.
what is an adverse drug event?
bad thing during/following drug therapy
what is an adverse drug reaction?
adverse drug event due to a drug, determined by causality assessment
what is accutane (isotretinoin)?
acne drug
