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Clinical Pharmacology > Adverse Drug Reactions > Flashcards

Adverse Drug Reactions Flashcards

Questions for the ADR lecture

1
Q

how many people on drug/placebo get ADR?

A

5%

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2
Q

how many people on drug/placebo get ADR?

A

5%

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3
Q

what is an adverse drug event?

A

bad thing during/following drug therapy

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4
Q

what is an adverse drug reaction?

A

adverse drug event due to a drug, determined by causality assessment

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5
Q

what is accutane (isotretinoin)?

A

acne drug

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6
Q

what is tegretol (carbamazepine)?

A

anti-epileptic

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7
Q

what is dilantin (phenytoin)?

A

anti-epileptic

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8
Q

ticlid (ticlopidine)

A

platelet inhibitor

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9
Q

zovirax (acyclovir)

A

antiviral

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10
Q

what are warning signs of acyclovir use?

A

hives, diff breathing, face swelling, lips, tongue, throat

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11
Q

what is a “type a” rxn?

A

augmented, what you would expect, dose related

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12
Q

what is a “type b” rxn

A

bizarre, off target, idiosyncratic, unexpected.

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13
Q

what is an example of a type a rxn?

A

digitalis

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14
Q

what is an example of a type b rxn?

A

phenytoin - anticonvulsant hypersensitivity syndrome - fever, rash, hepatitis, nephritis

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15
Q

SAFER MD?

A 
Side Effects
Alternative treatments
Forfeit of treatment
Expected benefit
Regimen

Monitoring tests/visits
Duration of therapy

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16
Q

What is a “high risk drug”?

A

Small Tx window, DDIs

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17
Q

What are the 4 anti’s?

A

Anti convulsants, biotics, coagulants, inflammatories

18
Q

What is a “high risk patient?”

A

Contrindications, warnings, age, general health, genetics

19
Q

High risk situation?

A

Drugs aren’t necessary, too many drugs, patient not competent

20
Q

What are contraindications for ticlid (ticlopidine)?

A

Hypersensitivity, bleeding problem, blood disorder, liver impairment.

21
Q

What are contraindications for ticlid (ticlopidine)?

A

Hypersensitivity, bleeding problem, blood disorder, liver impairment.

22
Q

what is an adverse drug event?

A

bad thing during/following drug therapy

23
Q

what is an adverse drug reaction?

A

adverse drug event due to a drug, determined by causality assessment

24
Q

what is accutane (isotretinoin)?

A

acne drug

25
Q

what is tegretol (carbamazepine)?

A

anti-epileptic

26
Q

what is dilantin (phenytoin)?

A

anti-epileptic

27
Q

ticlid (ticlopidine)

A

platelet inhibitor

28
Q

zovirax (acyclovir)

A

antiviral

29
Q

what are warning signs of acyclovir use?

A

hives, diff breathing, face swelling, lips, tongue, throat

30
Q

what is a “type a” rxn?

A

augmented, what you would expect, dose related

31
Q

what is a “type b” rxn

A

bizarre, off target, idiosyncratic, unexpected.

32
Q

what is an example of a type a rxn?

A

digitalis

33
Q

what is an example of a type b rxn?

A

phenytoin - anticonvulsant hypersensitivity syndrome - fever, rash, hepatitis, nephritis

34
Q

SAFER MD?

A 
Side Effects
Alternative treatments
Forfeit of treatment
Expected benefit
Regimen

Monitoring tests/visits
Duration of therapy

35
Q

What is a “high risk drug”?

A

Small Tx window, DDIs

36
Q

What are the 4 anti’s?

A

Anti convulsants, biotics, coagulants, inflammatories

37
Q

What is a “high risk patient?”

A

Contrindications, warnings, age, general health, genetics

38
Q

High risk situation?

A

Drugs aren’t necessary, too many drugs, patient not competent

39
Q

What do you do when an ADR happens?

A

Stop the drug
Consider alt therapy
Treat patient
Discuss with patient

40
Q

What are contraindications for ticlid (ticlopidine)?

A

Hypersensitivity, bleeding problem, blood disorder, liver impairment.

41
Q

what should you watch out for patients on ticlid?

A

falling neutrophils

42
Q

what lessons did you learn from the ticlid case?

A

you have to know serious rare reactions and know how to react when they happen.

Clinical Pharmacology (3 decks)

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