ADVANCED DELIVERY METHODS Flashcards
What does drug delivery/ targeting mean?
Delivery of a drug to its precise site of action at the right concentration for the right time
What are conventional dosage forms?
Drug release/ drug plasma levels depend on the physicochemical properties of the active ingredient
What are non-conventional dosage forms?
Drug release/drug plasma levels are determined by the technological characteristics of the formulation (e.g. modified release)
Can dopamine cross the blood brain barrier?
no
In what terms can a drug be ‘modified’?
(1) Rate
(2) Time
(3) Space
Why can L-DOPA cross the blood brain barrier where dopamine cannot?
Carboxylic acid group has been added
Is an amino acid
What are some ways in which ‘rate’ of a drug release can be changed?
(1) Very fast release
(2) Sustained release
How can ‘time’ of a drug release be changed?
When release starts after a certain time following administration
How can ‘space’ of a drug release be changed?
Occurs in specific areas/ tissues
Targeting
What is the objective of drug targeting?
Localise and concentrate drugs to the desired therapeutic site, avoiding all other tissues in the body
i.e. pharmacological response without the side-effects
What is first order drug targeting?
Organ/ tissue specificity
What is second order drug targeting?
Certain type of cell specificity
e.g. tumour cells
What is third order drug targeting?
Intracellular compartment specificity
e.g. lysosomes
What are three approaches to drug targeting?
(1) Magic bullet
(2) Prodrug
(3) Macromolecular carrier
What is the ‘magic bullet’ approach to drug targeting?
API is potent + selective
