Adult Urinary, Renal, Bladder disorder Flashcards
List 4 urinary, renal, and bladder disorders in ADULTS?
- Polycystic Kidney Disease
- Kidney cancer
- Bladder cancer
- Bladder trauma
Disorder:
genetic disorder where multiple cysts form in the kidneys, leading to kidney enlargement and possible kidney failure.
Polycystic Kidney Disease (PKD)
Disorder:
Injury to the bladder from external forces
Bladder Trauma
There are 2 forms of Polycystic Kidney Disease (PKD)
- Childhood (Recessive) PKD
- Adult (Dominant) PKD (ADPKD):
PKD that is Inherited in a recessive manner.
(inherrited from both parents)
Childhood (Recessive) PKD
PKD that is Inherited in a dominant manner.
(inherrited from one parent)
Adult (Dominant) Polycystic Kidney Disease (ADPKD)
S/S of PKD typically appear when cysts in the kidneys begin to ____.
enlarge.
PKD EARLY symptoms
List 8
- Nausea/vomiting
- Pruritus (itching)
- Fatigue
- Palpable bilateral enlarged kidneys (felt during a physical exam).
- Hematuria (blood in the urine) from cyst rupture.
- Urinary tract infections (UTI).
- Uremia (elevated BUN levels, indicating kidney dysfunction).
- Hypertension: decreased kidney function
Q: What are some associated complications of Polycystic Kidney Disease (PKD)?
- Liver cysts – Cysts can develop in the liver, affecting its function.
- Heart valve abnormalities – PKD can cause issues with heart valves, such as mitral valve prolapse.
- Diverticulosis – The development of small pouches in the walls of the intestines, which can become inflamed or infected.
- Aneurysms – Weakening of the blood vessel walls, particularly in the brain, which can lead to an increased risk of rupture and hemorrhage.
5 PKD Diagnosis include:
- DNA Testing: genetic mutation
- Family History: important for dominant form
- Clinical Manifestations
- **Ultrasound/CT scan
- IVP (Intravenous pyelogram)- detailed images of kidneys and urinary tract
Can patients with PKD progress to End Stage REnal Disease (ESRD)?
Yes!
About 50% of patients progress to ESRD by age 60.
What is the percent and age that patients with PKD progress to End stage Renal FAILURE
Renal disease and renal failure are diff- keep an eye!
70% by age 70
Is there a cure for PKD?
No. Treatment mainly focuses on managing symptoms and preventing complications
Collaborative Care for PKD
2 main ones
- Genetic Counseling: understand the risks of inheritance and potential implications for future generations
- Supportive Prevention/Treatment
Tx for ESRD and ESRF
List 3
- Nephrectomy (removal of kidneys) in some cases.
- Dialysis to filter waste and fluids from the body.
- Kidney Transplant as a potential long-term solution.
New Topic: Kidney Cancer
Most common type of malignant kidney tumor
adenocarcinoma
Q: What are the early symptoms of kidney cancer?
No “specific” early symptoms
- Makes early detection challenging
Risk factors for kidney Cancer
- Risk factors
- Smoking
- Family Hx
- Obesity
- HTN
- Exposure to asbestos, cadmium, gasoline
- Males > Females
Q: What are the classic manifestations of ADVANCED kidney cancer?
- gross hematuria: Blood in the urine
- flank pain: Pain in the side or back- tumor pressing on surrounding tissues.
- palpable mass
Kidney cancer spreads beyond kidneys to nearby structures such as
- Renal Vein
- Vena Cava
- lungs
- liver
- long bones
DX studies for Kidney Cancer
- Intravenous Pyelogram (IVP) with Nephrotomography – Detects most kidney masses.
- Ultrasound – Helps differentiate between a tumor and a cyst.
- Angiography, percutaneous needle aspiration, CT scan, and MRI
- Cystoscopy with a renal biopsy
What labs are needed PRIOR to Intravenous Pyelogram (IVP)
baseline BUN/Creatinine
- due to contrast dye used
What should you monitor post dx studies
Bleeding- procedures can cause bleeding.
What is a RADICAL NEPHRECTOMY surgery
- Entire kidney is removed.
- Removal of adrenal gland, surrounding fascia, part of ureter, & draining lymph nodes
How is Radical Nephrectomy performed?
- via laparoscopy (minimally invasive)
- or through an open approach, where an incision is made, usually around the 12th rib, to access the kidney.
What are the key** post-operative care** considerations for a patient following a radical nephrectomy?
- Pain control: PCA pump-patient controlled
- Maintain airway / C&DB / IS
- Monitor for S/S of infection / bleeding
- Position of comfort
- I&O, Indwelling catheter
-mild (pink) hematuria several days post-op is common - Electrolyte, BUN/Creat: assess function of remianing kidney
- Activity /driving restrictions 2 weeks minimum
Tx of choice for Kidney cancer
Partial or radical nephrectomy.
kidney cancer:
Radiation therapy is used ____
Palliatively
Q: Is chemotherapy an effective treatment for metastatic kidney cancer?
No, chemotherapy is not an effective treatment for metastatic kidney cancer
Type of ‘targeted therapy’ used for metastatic kidney cancer
kinase inhibitors (potent anti-neoplastics)
How do Kinase inhibitors work?
- work by blocking certain enzymes that help cancer cells grow.
- This helps slow down or stop the cancer from spreading.
- It’s a more focused treatment with fewer side effects compared to traditional chemotherapy.
Moving on to: Bladder Cancer
Risk factors for Bladder Cancer
- Cigarette smoking
- Exposure to dyes used in rubber & other industries
- Radiation for cervical cancer
- Cyclophosphamide (Cytoxan®) / Pioglitazone (Actos®)
Hallmark sign of Bladder cancer- often 1ST sign!
Painless Hematuria
(blood in urine w/o pain)
Besides painless hematuria, what other urinary symptoms are associated with bladder cancer?
- Frequency
- urgency
- dysuria
Q: What is the most reliable DX TEST for DETECTING BLADDER tumors?
Cystoscopy
Q: What DX test confirms a bladder cancer diagnosis?
Bladder biopsy
Is Chemotherapy possible with Bladder cancer?
Yes. Sometimes radiation is used with it.
2 types of treatments for Bladder Cancer
- Chemotherapy
- Surgery
List 2 ways Chemotherapy is administered.
- Systemic Infusion
- Intravesical Instillation
Chemo administration type:
chemotherapy drugs are given through an IV (PIV - Peripheral Intravenous Line), allowing them to circulate throughout the body.
Systemic Infusion
#1 thing to monitor for Systemic Infusion
Systemic Infusion
Chemo Administration Type:
- method involves placing chemotherapy drugs directly into the bladder through a catheter.
- Medication contacts the entire bladder wall and targets cancer cells locally.
Intravesical Instillation
Q: What are the 4 surgical treatment options for bladder cancer?
- Transurethral resection of bladder tumor (TURBT) with fulguration (electrocautery)
- Photocoagulation/Open loop resection with fulguration
- Partial cystectomy
- Cystectomy (bladder removal)
Which bladder surgical tx am I?
TURBT: Transurethral resection of bladder tumor with fulguration (electrocautery)
No. 1 Assessment POST TURBT
Assess for DVT post-op due to immobility.
Which bladder surgical tx am I?
Photocoagulation/ open loop resection with fulguration
Which bladder surgical tx am I?
Partial cystectomy
- Removes a portion of the bladder while preserving function.
Which bladder surgical tx am I?
Cystectomy (bladder removal)
– Requires urinary diversion to reroute urine since the bladder is no longer present.
Post-OP Bladder Cancer Surgery:
What is the desired urinary output range to monitor in a post-op urology patient?
A: 30-60 mL/hr.
Post-OP Bladder Cancer Surgery:
If catheter present post bladder surgery, what should you perform on this catheter?
irrigate a catheter gently with 60 mL of NS
Post-OP Bladder Cancer Surgery:
What complications should be monitored for in a patient with a urinary catheter?
- Hematuria (blood in urine)
- peritonitis
- bladder distention
- shock
- hemorrhage: excessive bleeding due to blood vessel damage
- thrombophlebitis.
Post-OP Bladder Cancer Surgery:
What is used after bladder surgery to collect urine when normal bladder emptying is not possible?
Urinary drainage pouch
What 2 important things should be monitored Post bladder cancer surgery.
- Monitor the urinary drainage pouch.
- Monitor the pH of the urine – keep acidic.
Q: Why should the pH of urine be monitored and kept acidic?
A: To reduce the risk of infection and stone formation.
3 Types of Urinary Diversion Techniques
- Indiana Pouch Reservoir
- Kock Pouch Reservoir
- Neobladder to Urethra Diversion
1st type of Urincary Diversion:
What type of urinary diversion uses tissue from the LARGE intestine to create a pouch and the small intestine for the outlet?
A continent urinary diversion called Indiana pouch
What does CONTINENT urinary diversion mean?
- the ability to control the release of urine or stool
- urine is stored internally in a pouch and can be emptied voluntarily with a catheter, rather than continuously draining into an external bag
How is urine drained in an Indiana Pouch?
By inserting a catheter through the stoma 3 to 6 times daily
2nd type of Urinary Diversion:
A type of urinary diversion that uses the SMALL intestine to make the pouch, valves, and outlet.
Kock Pouch Reservoir
What part of the small intestine is used in Kock Pouch Reservoir?
Terminal ileum
Is the Kock pouch considered a continent urinary diversion?
Yes!
catheter is also placed in stoma 3 to 6 times daily to drain urine.
3rd type of Urinary DIversion:
A segment of the intestine is made into a new bladder (reservoir) and connected to the urethra, allowing urine to be expelled naturally.
Neobladder to Urethra Diversion
Neobladder = “new bladder”
Is Neobladder + urthra considered a ‘continent diversion’?
Yes bc urine collects internally and emptied VOLUNTARILY, and not continuous into a urine bag.
What must a patient relearn to do with a Neobladder to Urethra diversion?
Relearn to urinate since the neobladder cannot contract or squeeze out urine like a bladder.
- Use abdominal muscles to create pressure and push urine out.
- Practice timed voiding (urinating at set intervals Q2-4 hrs.) to prevent overfilling, since they may not feel the usual urge to urinate.
Which one am I?
Kock Pouch Resorvoir
Which one am I?
Indiana Pouch Reservoir
Which one am I?
Neobladder to Urethra Diversion
(new bladder is made from the small intestine and connected to the urethras)
What are the 3 important pre-operative assessments for a patient undergoing urinary diversion surgery?
- Cardiopulmonary assessment: heart & lung fuction.
- Nutritional assessment: healing and recovery, more fiber.
- Evaluation of readiness to learn : assessing anxiety and knowledge deficit.
What are the pre-operative goals for a patient undergoing urinary diversion surgery?
- Relief of anxiety through education and support.
- Adequate nutrition for optimal healing.
- Understanding the procedure, including the stoma’s appearance and care after surgery.
Why is it important to educate the patient about stoma appearance and care preoperatively?
To reduce anxiety, promote self-care, and prepare the patient for life after surgery.
11 Key Assessments for KIDNEY & BLADDER Trauma
- History of Injury
- Anuria (no urine)
- Hematuria (blood in urine)
- Flank / Pelvic Pain
- Suprapubic Pain
- Guarding
- Dysuria (painful urination)
- Difficulty / Inability to Void
- Nausea and vomiting
- Abdominal Distention
- Rebound Tenderness (pain upon releasing pressure from abdomen-indicate bladder rupture or internal bleeding)
6 Diagnosis to detect Kidney & Bladder Trauma
- Hematuria (UA)
- Ultrasound
- CT (with barium contrast)
- MRI
- IVP with cystography
- Renal arteriography
CT & MRI done before IVP
Kidney/Bladder DX:
Q: Why is renal trauma often associated with bowel trauma?
The kidneys and bowel are in close proximity within the abdomen, so trauma (blunt or penetrating) can affect both organs simultaneously
Kidney/Bladder DX:
Q: What imaging tests are used to assess BOTH renal and bowel injury?
Abdominal CT and X-ray with contrast (barium)
How is Barium administered?
Oraly (barium swallow)
or
Rectally (barium enema)
Kidney/Bladder DX:
What does Barium Contrast do?
Barium contrast helps highlight the GI tract BUT blocks visualization of other organs like the kidneys.
Kidney/Bladder DX:
When should barium contrast be administered/scheduled?
Barium contrast should be scheduled AFTER THE IVP IS COMPLETE because it obstructs the kidney’s visualization during the imaging process.
IVP done 1st, Barium done 2nd.- KNOW THIS!!!!
What is most commonly used the most:
IV contrast or Barium?
IV contrast bc its doesnt obstruct views like barium does.