ADULT HEMATOPOIESIS (EXTRAUTERINE)

Question 1

BONE MARROW CONTAINS

Answer 1

developing erythroid, myeloid, megakaryocytic, and

lymphoid cells

Question 2

TYPES OF LYMPHOID TISSUE

Answer 2

PRIMARY LYMHPOID ORGAN

SECONDARY LYMPHOID ORGAN

Question 3

PRIMARY VS SECONDARY LYMPHOID ORGAN, WHAT ARE THEIR DIFFERENCES

Answer 3

primary lymphoid tissue consists
of the bone marrow and thymus and is where T and B lymphocytes are derived. Secondary lymphoid tissue, where lymphoid
cells respond to foreign antigens, consists of the spleen, lymph
nodes, and mucosa-associated lymphoid tissue

Question 4

MAJOR COMPONENTS OF BM

Answer 4

red
marrow, hematopoietically active marrow consisting of the developing blood cells and their progenitors, and yellow marrow,
hematopoietically inactive marrow composed primarily of adipocytes (fat cells), with undifferentiated mesenchymal cells
and macrophages. there is approximately equal amounts of red and yellow
marrow

Question 5

RED BONE MARROW CHARACTERISTICS

Answer 5

ALL BONES IN BODY contain REDBM during INFANCY AND CHILDHOOD
*Reduces @ 5-7 years of age
* HEMATOPOIETICALLY ACTIVE SITE
* ACTIVE RedBM in Adults are: sternum, vertebrae, scapulae, pelvis, ribs, skull, and proximal portion of the
long bones

Question 6

YELLOW BM Characteristics

Answer 6

• HEMATOPOIETICALY INACTIVE
• Composed of fat cells (adipocytes)
• capable of reverting back to an active red marrow in cases of increased demand of blood

Question 7

The process of replacing

the active marrow by adipocytes (yellow marrow) during development

Answer 7

RETROGRESSION, where yellow marrow becomes more abundant and occupy the spaces in the long bones previously dominated by the active marrow

Question 8

What are the cells that release eryhtopoietin

Answer 8

Peritubular cells in the kidney

Question 9

What are the cells that provide a microenvironment in bone marrow, for the development of other cells?

Answer 9

Stromal cells (adipocytes, fibroblasts, reticuloendothelial cells)