Adult GI Flashcards
What are the 3 major mechanisms responsible for GERD?
- transient lower esophageal (LES) relaxation
- increased abdominal pressure
- Low resting sphincter tone
What dietary factors affect GERD?
- smoking
- caffeine
- ETOH
- chocolate
- peppermint
What medications affect GERD?
- tricyclics
- antidepressants
- diazepam
- CCBs
What is Barrett’s esophagus?
- changes seen in the esophagus after repeated exposure to acid
- columnar epithelium lined lower esophagus (CELLO)
- metaplasia, precancerous
What will endoscopy rule out when considering GERD?
strictures
Barrett’s
delayed emptying
What are the grades of the Los Angeles Classification System for Erosive Esophagitis?
- None- no breaks but may have edema, erythema, friability
- Grade A- one or more mucosal breaks
- Grade B- 1+ breaks >5mm but not continuous
- Grade C- breaks continuous between tops of two or more mucosal folds
- Grade D- breaks > 75% of esophageal circumference
What is first line for mildly erosive GERD?
H2 receptor agonists (cimetidine, famotidine, ranitidine, nizatidine)
What is first line for severe erosive esophagitis?
PPI
What are the side effects of long term PPI use (> 12 mo)?
- B12, mag, zinc deficiencies
- possibly arrhythmias
- increased risk of fracture
What are the most common causes of pancreatitis
80% caused by either ETOH (chronic) or gallstones (acute)
What is the mnemonic for pancreatitis (GET SMASHED)?
G- gallstones E- ethanol T- trauma S- steroids M- mumps A- autoimmune S- scorpion sting H- hyper lipids, hypothermia, hyperparathyroid E- ERCP D- drugs (steroids, depakote, metformin)
What diet should patients with chronic pancreatitis follow?
- low fat (minimizes gallbladder stimulation)
- high-carb, high-protein (provides increased nutrients in the setting of malabsorption)
- NO ETOH
What is the patho of cirrhosis?
Abnormal blood vessel distribution + fibrosis of vessels = overgrowth of connective tissue
How does ascites form?
Build up of fluid in the abdomen that the liver is supposed to process
What are the major causes of cirrhosis?
- ETOH (20 %)
- Hep B (30 %), Hep C (27 %)
- Fatty liver disease
What are the s/s of cirrhosis?
telangiectasis, spider angiomata palmar erythema gynecomastia hypogonadism hepatomegaly ascites factor hepaticas (musty breath) jaundice
What are the major complications of cirrhosis?
- portal HTN
- varices
- peripheral edema
- ascites
- encephalopathy
- hepatorenal syndrome