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PR1153 > ADRs and the causative drugs > Flashcards

ADRs and the causative drugs Flashcards

1
Q

Fixed drug eruptions (skin), Type 4 HS rxn (delayed)
-red patches, may blister

A

antibiotics (penicillins, rifampicin, quinolones, co-trimoxazole), antifungals, antiepileptics (carbamarzepine), NSAIDs (aspirin, ibuprofen, naproxen), Paracetamol, Antihypertensives

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2
Q

Erythema Multiform. (skins)
-targetoid lesions, raised oedematous papules

A

sulfonamides (co-trimoxazole), sulfonylureas, antiepileptics (phenytoin, carbamazepine, barbiturates), antibiotics (penicillin, tetracyclines, cephalosporins, rifampicin), anti TB agents (isoniazid)

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3
Q

SJS/TEN (skin), Type 4 HS rxn
-widespread rash (red patches, targetoid lesions/blisters), can be life-threatening

A

Sulfonamides (cotrimoxazole), beta-lactams (penicillin, cephalosporins), antiepileptics (phenytoin, carbamarzepine, phenobarbitone), anti-gout (Allopurinol), paracetamol, NSAIDs

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4
Q

Hepatocellular necrosis (liver)

A

paracetamol, immunosuppressant (methotrexate), salicylates, Vit A

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5
Q

Acute fatty liver (liver)

A

Tetracycline (through IV)

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6
Q

Granulomatous hepatitis (liver)

A

NSAIDs (Phenylbutazone), hydralazine, allopurinol

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7
Q

Focal nodular hyperplasia (liver)

A

OCPs

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8
Q

Liver cell adenoma (benign tumor)

A

OCPs, anabolic steroids

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9
Q

Gastritis (GIT)

A

NSAIDs

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10
Q

Peptic Ulcers (GIT)

A

NSAIDs, CCS

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11
Q

Jejunal Ulcers (GIT)

A

Enteric-coated potassium

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12
Q

Psuedomembranous colitis (GIT)

A

Antibiotics

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13
Q

Gingival hyperplasia (GIT)

A

Phenytoin

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14
Q

Acute tubulo-interstitial nephritis (urinary)

A

methicillin, rifampicin, sulfonamides

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15
Q

acute tubular necrosis (urinary)

A

Gentamicin

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16
Q

analgesic nephropathy (papillary necrosis) (urinary)

A

compound analgesics containing phenacetin, acetaminophen, NSAIDs

17
Q

Haemorrhagic cystitis (urinary)

A

Cyclophosphamide

18
Q

myelosuppression (bone marrow)

A

chemotherapeutic agents, cytotoxic agents

PR1153 (3 decks)

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