ADRs

Question 1

Mupirocin

Answer 1

Few

Question 2

Oxazolidinones

Answer 2

Reversible thrombocytopenia and anaemia. Abnormal LFTs

Question 3

Tetracyclines

Answer 3

Chelate metal ions and deposit in bone and teeth. Photosensitivity.

Question 4

Aminoglycosides

Answer 4

Neuromuscular blockade, ototoxicity, nephrotoxicity.

Question 5

Chloramphenicol

Answer 5

Grays syndrome in young and myelosuppression

Question 6

Macrolides

Answer 6

GI disturbance, jaundice and ototoxicity

Question 7

Fusidic Acid

Answer 7

N + V, abdo pain

Question 8

Trimethoprim

Answer 8

Folate deficiency

Question 9

Sulphonamides

Answer 9

Hepatitis, myelosuppression, AKI from interstitial nephritis and crystalluria.

Question 10

Beta-lactams

Answer 10

Allergy to metabolite

Question 11

Vancomycin

Answer 11

Ototoxicity, Nephrotoxicity, Reversible thrombocytopenia and neutropenia. RED MAN syndrome

Question 12

Polymyxins

Answer 12

Neurotoxic and nephrotoxic.

Question 13

Daptomysin

Answer 13

Muscle toxicity.

Question 14

Quinilones and fluroroquinilones

Answer 14

Tendonitis, GI upset, phototoxcity. CI in young and pregnant due to arthropathy.

Question 15

Metronidazole/Nitroimidazoles

Answer 15

+alcohol increase acetylaldehyde and feel awful. Reversible neutropenia. Vague research on carcinogenic, mutagenic and teratogenic.

Question 16

Rifamycin

Answer 16

Change urine colour, skin reaction, flu-like symptoms and hepatitis.

Question 17

NRTI

Answer 17

Peripheral neuropathy, headache, anaemia, GIU upset

Question 18

Ribavirin

Answer 18

Cytotoxic and haemolytic anaemia (may not be reversible!)

Question 19

Polyene/Amphotericin B

Answer 19

ACUTE INFUSION RELATED TOXICITY (hypotension, chills, fever), nephrotoxic.

Question 20

Pyrimidine/ Fluoroucytosine

Answer 20

Bone Marrow Suppression

Question 21

Terbinafine/Allyamine

Answer 21

Altered taste perception, liver dysfunction

Question 22

Echinocandins

Answer 22

Altered LFTs, fever, chills, nausea.

Question 23

Fluconazole

Answer 23

Headache, N+V, diarrhoea, abnormal LFTS

Question 24

Itraconazole

Answer 24

Headache, N+V, diarrhoea, abnormal LFTs, rash and shortness of breath.

Question 25

Voriconazole

Answer 25

Headache, N+V, diarrhoea, abnormal LFTs, rash, peripheral oedema and visual abnormalities.

Question 26

Posaconazole

Answer 26

Headache, N+V, diarrhoea, abnormal LFTs and rash

Question 27

Bleomycin

Answer 27

Pulmonary fibrosis

Question 28

Alkylating agents

Answer 28

Increase risk of non-lymphocytic leukaemia, decrease gametogenesis, teratogenic.

Question 29

Platinum Coord Complexes

Answer 29

Nephrotoxic, vomiting, nausea.

Question 30

Topoisomerase 1 Inhibitors

Answer 30

Myelosuppression

Question 31

Taxanes

Answer 31

Neutropenia, bone marrow suppression, neurotoxicity, fluid retention.

Question 32

Vinca Alkaloids

Answer 32

Peripheral neuropathy, hair loss.

Question 33

Selective oestrogen receptor modulator

Answer 33

Act as weak agonist, max 5 years of treatment otherwise will increase tumour growth.

Question 34

Trastuzumab

Answer 34

Heart failure

Question 35

Rituximab

Answer 35

Hypotension, fever, cardiac pathologies

Question 36

Cetuximab

Answer 36

Fever, hypotension.

Question 37

Bevacizumab

Answer 37

Hypotension and interstitial bleeding

Question 38

Interleukin 2

Answer 38

Reversible hypotension and liver damage. Limit to 14 doses