Adrenic Drugs involved in transmission Flashcards
1
Q
Effect on adrenergic transmission:
Metyrosine
alpha-methyldopa
A
Affects synthesis of NE
2
Q
Effect on adrenergic transmission:
Reserpine
Tyramine
A
Affects Storage of NE
3
Q
Effect on adrenergic transmission:
TTX,
verampamil,
bretyllium
A
Affects Release of NE
4
Q
Effect on adrenergic transmission:
Cocaine
Amphetamine
TCA (Amitriptyline)
A
Affects reuptake of NE
5
Q
Effect on adrenergic transmission:
MAO inhibitor (phenelzine) COMT inhibitor (entacapone)
A
Metabolism of NE
6
Q
Physiological response associated with:
alpha 1 receptor
A
- vasoconstriction
- increased peripheral resistance
- increased blood pressure
- mydriasis
- increased closure of internal sphincter of bladder
7
Q
Physiological response associated with:
alpha 2 receptor
A
- inhibition of NE release
- Inhibition of insulin release
8
Q
Physiological response associated with:
beta 1 receptor
A
- Tachycardia
- increased lipolysis
- Increased myocardial contractility
9
Q
Physiological response associated with:
beta 2 receptor
A
- vasodilation
- slightly decreased peripheral resistance
- bronchodilation
- increased muscle and liver glycogenolysis
- increased release of glucagon
- relaxed uterine smooth muscle
