Adrenergics Flashcards
alpha agonists: 2
Phenylephrine (Neo-synephrine), Clonidine (Catapres)
Mixed alpha and Beta agonists: 2
Norepinephrine (Levophed), Epinephrine (Adrenalin)
Beta agonists: 4
Dobutamine (Dobutrex), Isoproterenol (Isuprel), Terbutaline (Brethine), Albuterol (Ventolin)
Dopamine agonists: 2
Dopamine (Intropin), Fenoldopam (Corlopam)
Direct acting adrenomimetics: 4
Alpha agonists, mixed alpha/beta agonists, beta agonists, dopamine agonists
Indirect adrenomimetics: 4
Inhibitors of re-uptake of DA/NE, inhibitors of MAO, reverse NE/DA uptake mechanisms that increase their release, Releasing agent AND a direct adrenergic receptor agonist
Drug that inhibits re-uptake of DA and NE
-family
cocaine, indirect adrenomimetic
Two inhibitors of MAO
-what family
Selegiline (Eldepryl), and Phenelzine (Nardil)
they are indirect adrenomimetics
Three drugs that reverse NE and DA uptake mechanisms and increase their release
-what family
Amphetamines, Methylphenidate (Ritalin), Tyramine (not actually a drug but byproduct of tyrosine metabolism)
-they are indirect adrenomimetics
Drug that is a releasing agent AND a direct adrenergic receptor agonist
-what family
- Ephedrine
- indirect adrenomimetic
Direct acting antiadrenergic drugs
-3 broad classes
a-adrenoceptor antagonists, Mixed blockers, B-adrenoceptor blockers
- Two non selective (a1 and a2) receptor antagonists
- names of drugs
Phentolamine (OraVerse), Phenoxybenzamine (Dibenzyline)
a1 receptor selective drugs (6)
Prazosin (Minipress), Terazosin (Hytrin), Tamsulosin (flomax), Doxazosin (cardura), Alfuzosin (Uroxatral), Silodosin (Rapaflo)
Mixed blockers: two drugs that are Beta and a1 antagonists
Labetalol (Trandate) and Carvedilo (Coreg)
B-adrenoceptor blockers
-classes
B1 and B2 blockers, B1 selective
B1 and B2 blockers (4)
Propanolol (inderal), Pindolol (visken), Nadolol (corgard), Penbutolol (Levatol)
B1 selective blocker (4)
Metoprolol (Toprol), Betaxolol (Kerlone), Acebutolol (Sectral), Atenelol (Tenormin)
classes of indirect acting antiadrenergic drugs (2) and examples of those classes
Norepinephrine release inhibitor, inhibitors of tyrosine hydroxylase
NE inhibitor: Guanethidine (Ismelin)
Tyrosine OHase: Metyrosine (Demser)
What do adrenomimetics/sympathomimetics do?
mimic or promote the effects of NE, Epi, DA at adrenergic receptors in the sympathetic nervous system
Drugs that inhibit adrenergic transmission (sympatholytics or antiadrenergic drugs) prevent what?
prevent the effects of NE/Epi/DA at adrenergic receptors in the sympathetic nervous system
a1 type receptors
a1A, a1B, a1D:
-what G protein, what effects?
Gq protein
increase IP3, DAG
a2 type receptors
a2A, a2B, a2C
-what G protein, what effects?
Gi protein, decrease cAMP
B type receptors
B1, B2, B3
-which G protein, what effects?
Gs protein, increase cAMP
Dopamine type receptors
D1 and D5:
-which G protein, what effect
Gs protein, increase cAMP
