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Neuro 2 Exam 1 > Adrenergics > Flashcards

Adrenergics Flashcards

1
Q

alpha agonists: 2

A

Phenylephrine (Neo-synephrine), Clonidine (Catapres)

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2
Q

Mixed alpha and Beta agonists: 2

A

Norepinephrine (Levophed), Epinephrine (Adrenalin)

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3
Q

Beta agonists: 4

A

Dobutamine (Dobutrex), Isoproterenol (Isuprel), Terbutaline (Brethine), Albuterol (Ventolin)

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4
Q

Dopamine agonists: 2

A

Dopamine (Intropin), Fenoldopam (Corlopam)

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5
Q

Direct acting adrenomimetics: 4

A

Alpha agonists, mixed alpha/beta agonists, beta agonists, dopamine agonists

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6
Q

Indirect adrenomimetics: 4

A

Inhibitors of re-uptake of DA/NE, inhibitors of MAO, reverse NE/DA uptake mechanisms that increase their release, Releasing agent AND a direct adrenergic receptor agonist

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7
Q

Drug that inhibits re-uptake of DA and NE

-family

A

cocaine, indirect adrenomimetic

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8
Q

Two inhibitors of MAO

-what family

A

Selegiline (Eldepryl), and Phenelzine (Nardil)

they are indirect adrenomimetics

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9
Q

Three drugs that reverse NE and DA uptake mechanisms and increase their release

-what family

A

Amphetamines, Methylphenidate (Ritalin), Tyramine (not actually a drug but byproduct of tyrosine metabolism)

-they are indirect adrenomimetics

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10
Q

Drug that is a releasing agent AND a direct adrenergic receptor agonist

-what family

A
  • Ephedrine
  • indirect adrenomimetic
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11
Q

Direct acting antiadrenergic drugs

-3 broad classes

A

a-adrenoceptor antagonists, Mixed blockers, B-adrenoceptor blockers

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12
Q
  • Two non selective (a1 and a2) receptor antagonists
  • names of drugs
A

Phentolamine (OraVerse), Phenoxybenzamine (Dibenzyline)

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13
Q

a1 receptor selective drugs (6)

A

Prazosin (Minipress), Terazosin (Hytrin), Tamsulosin (flomax), Doxazosin (cardura), Alfuzosin (Uroxatral), Silodosin (Rapaflo)

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14
Q

Mixed blockers: two drugs that are Beta and a1 antagonists

A

Labetalol (Trandate) and Carvedilo (Coreg)

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15
Q

B-adrenoceptor blockers

-classes

A

B1 and B2 blockers, B1 selective

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16
Q

B1 and B2 blockers (4)

A

Propanolol (inderal), Pindolol (visken), Nadolol (corgard), Penbutolol (Levatol)

17
Q

B1 selective blocker (4)

A

Metoprolol (Toprol), Betaxolol (Kerlone), Acebutolol (Sectral), Atenelol (Tenormin)

18
Q

classes of indirect acting antiadrenergic drugs (2) and examples of those classes

A

Norepinephrine release inhibitor, inhibitors of tyrosine hydroxylase

NE inhibitor: Guanethidine (Ismelin)

Tyrosine OHase: Metyrosine (Demser)

19
Q

What do adrenomimetics/sympathomimetics do?

A

mimic or promote the effects of NE, Epi, DA at adrenergic receptors in the sympathetic nervous system

20
Q

Drugs that inhibit adrenergic transmission (sympatholytics or antiadrenergic drugs) prevent what?

A

prevent the effects of NE/Epi/DA at adrenergic receptors in the sympathetic nervous system

21
Q

a1 type receptors

a1A, a1B, a1D:

-what G protein, what effects?

A

Gq protein

increase IP3, DAG

22
Q

a2 type receptors

a2A, a2B, a2C

-what G protein, what effects?

A

Gi protein, decrease cAMP

23
Q

B type receptors

B1, B2, B3

-which G protein, what effects?

A

Gs protein, increase cAMP

24
Q

Dopamine type receptors

D1 and D5:

-which G protein, what effect

A

Gs protein, increase cAMP

25
Q

Dopamine type receptors

D2, D3, D4:

  • which G protein
  • what effect
A

Gi protein, decrease cAMP

26
Q

Steps of a1 receptor activation:

A
  • stimulation of receptor by catecholamine leads to activation of a Gq coupling protein
  • activated alpha subunit of the G protein activates the effector, phospholipase C
  • this causes the release of IP3 and DAG from PtdINs.
  • IP3 stimulates release of calcium, leading to increase cytoplasmic Ca
  • Ca then can activate Ca dependent protein kinases which phosphorylate their substrates
  • DAG activates protein kinase C

Neuro 2 Exam 1 (7 decks)

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