Adrenergic System Flashcards
1
Q
Noradrenaline (norepinephrine)
A
- neurotransmitter
- treatment of shock
2
Q
Guanethidine
A
-blocks release of vesicles containing noradrenaline
3
Q
Tricyclic antidepressants/ Cocaine
A
- indirects adrenergic agonists
- inhibit neuronal uptake (uptake 1)
4
Q
Phenylephrine
A
- alpha 1 agonist
- noncatecholamine
- vasoconstriction
- treats: 1)nasal decongestion
5
Q
Isoproterenol
A
- nonselective beta agonist
- bronchodilation, increase cardiac output, peripheral vasodilation
6
Q
Clonidine
A
- alpha 2 agonist (indirect adrenergic antagonist)
- treats hypertension (vasodilation)
7
Q
Dobutamine
A
- beta 1 agonist
- increase cardiac output (especially useful for congestive heart failure)
8
Q
Salbutamol
A
- beta 2 agonist
- bronchodilator in asthma
9
Q
Amphetamine
A
- indirect adrenergic agonist
- displace NA vesicles causing them to release into the synapse
10
Q
Tyramine
A
- indirect adrenergic agonist
- displace NA vesicles causing them to release into the synapse
- found in fermented food like cheese
- metabolized by MAO
- MAO inhibition enhances indirect adrenergic agonists leading to hypertensive crisis
11
Q
Ephedrine
A
-mixed action adrenergic agonists
12
Q
Phentolamine
A
-non-selective alpha blocker
13
Q
Prazosin
A
- alpha 1 blocker
- treats hypertension
14
Q
Yohimbine
A
-alpha 2 blocker
15
Q
What are the therapeutic uses of alpha blockers
A
- treats hypertensive crisis due to phaeochromocytoma
- relieves urinary retention cause by benign prostatic hyperplasia
- treats Raynauds disease
