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Nervous System Pharmacology > Adrenergic's > Flashcards

Adrenergic's Flashcards

1
Q

Metyrosine:

MOA, Therapeutic use?

A

Tyrosine Hydroxylase Inhibitor
(STOP! TyrosineDOPA)

Pheochromocytoma : Decrease NE, Epi

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2
Q

Tyramine:

MOA, where is it found, ADR?

A

Enters neuron via amine pump
Increase NE, Epi release
Dietary constituent, wine/ cheese

HTN crisis if combined with MAOi

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3
Q

Amphetamine:
MOA
Therapeutic uses

A

Increase NE/ epi release

ADHD, narcolepsy
^ TPR/ HR
CNS stimulation

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4
Q

Cocaine:

MOA

A

Decreases NE reuptake at synaptic cleft

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5
Q

Tranylcycloprine:
MOA
Therapeutic Use
ADR

A

MAOi
Anti-depressant

HTN Crisis (increase circulating dietary amines)

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6
Q

Phenelzine:
MOA
Therapeutic Use
ADR

A

MAOi
Anti-depressant

HTN Crisis (increase circulating dietary amines)

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7
Q

Entacapone:
MOA
Therapeutic use

A

COMTi
Adjunct to Parkinsonism therapy
(give with levo/carbidopa)

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8
Q

Phenylephrine:
MOA + Effects
Therapeutic Use
Adverse effects

A

A1 agonist
^TPR/ BP
Decreased HR (reflex)

Ophtho, decongestant, ^ duration local anesthesia (vasoconstrxn.)

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9
Q

Clonidine:
MOA
Therapeutic Use
Adverse Effects

A

A2 agonist; sympatholytic
Decrease TPR/ BP, ^ HR (reflex)

HTN
ADHD
Drug addiction

Sedation, sexual dysfunction, HTN with sudden w/draw

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10
Q

Albuterol:
MOA
Therapeutic Use
Adverse Effects

A

B2 agonist
Reflex ^ HR
Asthma

High dose = Loss of selectivity–> B1 Activity–> cardiac stimulation
Tremor

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11
Q

Isoproterenol:
MOA
Therapeutic Use
Adverse effects

A 
B1/2 agonist 
Decreased TPR/ BP, ^ HR 
- Bronchospasm
- Heart block
- Cardiac arrest

ADR: Tremor

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12
Q

Epinephrine:
MOA
Therapeutic Use
Adverse effects

A

A1-2; B1-2 agonist
LOW DOSE: B2+1»>
Decrease TPR/ BP; ^HR

HIGH DOSE: A1»>
^TPR/BP/HR

Anaphylaxis
Cardiac Arrest
Bronchospasm
Glaucoma 
^ Duration local anesthesia

ADR: Hyperglycemia, CNS stimulation, etc. (too much of any receptor)

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13
Q

Norepinephrine:
MOA
Therapeutic Use
Adverse Effects

A

A1-2, B1 Agonist
^TPR/ BP, +/-HR

Septic/ cardiogenic shock

ADR: Hyperglycemia, CNS stimulation, etc. (too much of any receptor)

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14
Q

Dobutamine:
MOA
Therapeutic Use
Adverse Effects

A

A1, B1-2 agonist
Increased CO

Acute CHF

ADR: Arrhythmia, ^myocardial O2; ^ AV nodal conduction

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15
Q

Which Drugs are Catecholamines and what do they have in common?

A 
DINED: 
Dopamine
Isoproterenol
Norepinephrine
Epinephrine
Dobutamine

IV/ subQ only; rapidly metabolized

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16
Q

A1 Receptor (3)

A
  • mydriasis
  • GI/GU sphincter contraction + orgasm
  • vasoconstriction
17
Q

B1 Receptor (3)

A
  • Increase renin
  • Increase cardiac fxn
  • Increase lipolysis
18
Q

B2 Receptor (4)

A
  • Dilate uterus
  • Dilate bronchi
  • Dilate vasculature
  • Increase insulin, gluconeogenesis, glycogenolysis
19
Q

A2 Receptor (3)

A

Sympatholytic:

  • Decrease NE/ Epi
  • Decrease CNS sympathetic output
  • Decrease Insulin
20
Q

Dopamine:
MOA
Therapeutic Uses
ADR

A

D1, B1, A1-2 agonist + NE/ epi release
Cerebral, coronal, splanchnic, renal, vasodilation

Low: vasodilation only
Mod: Lower TPR, ^ HR/CO +/- BP
High: ^TPR/ HR/ BP

Shock or acute CHF

ADR: Hyperglycemia, CNS stimulation etc

21
Q

Pseudophedrine:
MOA
Therapeutic Use
ADR

A

Direct agonist + NE release
Nasal decongestant
HTN/ insomnia

22
Q

Phenoxybenzamine:
MOA
Therapeutic Use
ADR

A

A1/2 antagonist- noncompetitive
Decreased TPR/ ^HR
Pheochromocytoma

ADR: Angina

23
Q

Phentolamine:
MOA
Therapeutic Use
How is it administered?

A

A1/2 antagonist- competitive
HTN crisis, vasospasm (frostbite),
Pheochromocytoma

*IV ONLY
Faster onset and shorter duration of action than phenoxylbenzamine

24
Q

Doxazosin:
MOA
Therapeutic Use
ADR

A

A1 antagonist
BPH/ HTN

ADR: First dose syncope; start regimen at night

25
Q

Tamsulosin:
MOA
Therapeutic Use
ADR

A

A1a antagonist
- selective for sphincter; BPH

ADR: Orthostatic HTN

26
Q

Propanolol:
MOA
Therapeutic Use
ADR/Contraindicaitons

A

B1/2 competitive antagonist
Decreased cardiac function, blood flow, BP etc.

Tx: 
HTN
angina
arrhythmia post MI
pheo
migraine
idiopathic hypertrophic subarortic stenosis 
stage fright, tremors 
ADR/ Contraindications: 
AV block 
Raynauds 
Variant angina 
DM- inhibits tacky in response to hypoglycemia; increases insulin induced hypoglycemia
27
Q

Timolol:
MOA
Therapeutic Use
ADR/ Contraindications

A

B1/2 competitive antagonist
Same as propranolol- better for glaucoma

ADR/ Contraindications: 
AV block 
Raynauds 
Variant angina 
DM- inhibits tacky in response to hypoglycemia; increases insulin induced hypoglycemia
28
Q

Carvedilol:
MOA
Therapeutic use

A

A1, B1-2 antagonist
Decreased TPR, BP, HR, CO

^ HDL

Tx: HTN, CHF

29
Q

Metoprolol:
MOA
Therapeutic Use
ADR

A

B1 antagonist

Propranolol uses + CHF
DOC for DM, Raynauds, and COPD

30
Q

Esmolol:
MOA
Therapeutic Use
Metabolism*?

A

B1 antagonist
IV antiarrythmic

*Metabolized by red cell esterase; very short t 1/2

31
Q

Nebivolol:
MOA
Therapeutic Use

A

B1 antagonist + NO release

HTN

Nervous System Pharmacology (3 decks)

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