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Autonomics > Adrenergic Receptor Subtypes, Location, Function > Flashcards

Adrenergic Receptor Subtypes, Location, Function Flashcards

1
Q

Major blood vessels and vasculature in dermal, GI, renal, bladder, nasal membranes (excluding skeletal/hepatic)

A

Vasoconstriction of major blood vessels –> ↑PR ↑DBP

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2
Q

Eyes

A 
A1= mydriasis (contraction of radial muscle --> mydriasis)
A2= ↓aqueous humor production
B1/B2= ↑ aqueous humor
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3
Q

Bladder & GI Sphincters

A

A1= constriction of sphincter, decreasing outflow

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4
Q

Pancreatic Islets

A

A2= inhibit insulin secretion –> ↑ [glucose]

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5
Q

Presynaptic nerve terminals

A

A2= activating autoreceptors = ↓NT release = ↓BP

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6
Q

CNS/ Brainstem

A

A2= ↓BP & inhibit baroreflex

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7
Q

Spinal cord

A

A2= inhibit pain transmission

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8
Q

Nasal Vasculature

A

A2= vasoconstriction of the nasal vasculature

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9
Q

Heart

A

B1= ↑HR, ↑contractility, ↑force == ↑CO –> ↑SBP

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10
Q

Kidney

A

B1 = ↑renin secretion, = vasoconstriction

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11
Q

Hepatic/Skeletal muscle, vascular smooth muscle

A

B2= relaxes smooth muscle = ↑ blood flow to the liver and skeletal muscle

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12
Q

pulmonary smooth muscle

A

B2 relaxes SM = bronchodilation to ↑airflow

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13
Q

GI longitudinal smooth muscle

A

B2 relaxes SM = ↓motility (don’t need to be digesting food while running for your life)

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14
Q

bladder detrusor muscle

A

B2 relaxes = ↓ outflow

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15
Q

pregnant uterus (myometrium)

A

B2 relaxes

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16
Q

skeletal muscle

A

B2 = ↑glycogenolysis to ↑K+ uptake

17
Q

mast cells

A

B2 inhibits mast cell degranulation –> inhibit histamine release

18
Q

liver

A

B2 = ↑ glycogenolysis = ↑[glucose]

19
Q

pancreas

A

B2 = ↑ glucagon release = ↑ [glucose]

20
Q

A1 receptor

A

G alpha Q

↑PLC –> ↑IP3, DAG, ↑Ca (increasing Ca is going to stimulate SM contraction)

21
Q

A2 receptor

A

G alpha I (inhibitory)
↓ adenylyl cyclase & ↑K+ channels –>
↓cAMP (low cAMP = SM contraction, ↓HR & contractility)
↑K+ channels is going to inhibit presynaptic NT release –> tremors

22
Q

B (1,2,3)

A

G alpha s
↑ adenylyl cyclase –> ↑cAMP & ↑Ca++ (heart)
↑cAMP is going to relax smooth muscles, but ↑HR & contractility

Autonomics (1 decks)

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