Adrenergic Receptor Antagonists

Question 1

What are the mechanism, use, and side effects of propranolol?

Answer 1

Non selective β antagonist, used for angina, HTN, arrhythmias.
Side effects are bradycardia, sexual dysfunction, and bronchoconstriction

Question 2

What are the mechanism, use, and side effects of timolol?

Answer 2

Non selective β antagonist, used for glaucoma. Side effects include bradycardia, bronchoconstriction, and sexual dysfunction

Question 3

What are the mechanism, use, and side effects of the drugs metoprolol, atenolol, and bisoprolol? What generation are they?

Answer 3

2nd gen β1 anatagonists. Used for HTN, angina, arrhythmias, and CHF. Side effects are bradycardia and sexual dysfunction.

Question 4

What are the mechanism, use, and side effects of carvedilol and labetalol? What generation are they?

Answer 4

3rd gen “A” non selective β antagonists. Used for CHF and HTN. Side effects are bradycardia and fatigue.

Question 5

What is the mechanism, use, and side effects of betaxolol?

Answer 5

3rd gen “B” β1 selective antagonist. Used for CHF, HTN. Side effect is bradycardia.

Question 6

What are the mechanisms, uses, and side effects of phentolamine and phenoxybenzamine?

Answer 6

Nonselective α antagonist. Used to treat pheochromocytoma, Raynaud’s, and frostbite. Side effects are postural hypotension and inhibition of ejaculation.

Question 7

What is the mechanism, use, and side effects of prazosin?

Answer 7

α1 antagonist, treats primary HTN and BPH. Side effects are postural hypotension (1st dose)