Adrenergic Pharmacology II

Question 1

At what receptors do adrenaline and noradrenaline have the highest affinity?

Answer 1

The alpha receptors

Question 2

At what receptors does isoprenaline have the highest affinity?

Answer 2

The beta receptors- it is a selective beta agonist

Question 3

What G proteins are alpha 1 and 2 receptor coupled to?

Answer 3

Alpha 1 - Gq

Alpha 2 - Gi

Question 4

What effect does Prazosin have?

Answer 4

it is an antagonist of alpha 1 receptors

Question 5

What G proteins are beta 1 and 2 coupled to?

Answer 5

Both are coupled to Gs

Question 6

What is the effect of Propranolol?

Answer 6

It is a beta blocker, it selectively blocks beta 1 and 2 receptors

Question 7

What physiological effects does activation of alpha 1 have

Answer 7

• vasoconstriction
• bronchoconstriction
• relaxation of GI and smooth muscle

Question 8

What physiological effects does activation of alpha 2 have?

Answer 8

• vasoconstriction
• relaxation of GI smooth muscle
• decrease of NA release

Question 9

What physiological effects does the activation Beta 1 have?

Answer 9

causes and increase in the rate and force of contraction of the heart.

Question 10

What physiological effects doe the activation of Beta 2 have?

Answer 10

• vasodilation
• bronchodilation
• relaxation of GI and smooth muscle