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Pharmacology > adrenergic pharmacology > Flashcards

adrenergic pharmacology Flashcards

1
Q

what are the three catecholamines?

A

dopamine
noradrenaline
adrenaline

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2
Q

what is dopamine the precursor of?

A

adrenaline and noradrenaline!

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3
Q

What type of receptor are the adrenoceptors?

A

GPCRs

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4
Q

what are the actions of alpha 1 receptors?

A

contracts smooth muscle eg pupil and blood vessels - as alpha are excitatory mainly

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5
Q

what are the actions of alpha 2 receptors?

A

mixed effects on smooth muscle

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6
Q

what does stimulation of Beta 1 receptors do and where are they found?

A 
Chronotropic and
inotropic effects on
HEART
heart, intestine,
smooth muscle - inhibitory except in the heart
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7
Q

where are beta 2 receptors found and what are their actions?

A

bronchial, vascular,

uterine smooth muscle - inhibits contraction, as beta receptors are inhibitory mainly

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8
Q

what do beta 3 receptors result in?

A

Enhances lipolysis,
relaxes bladder
detrusor (so agonists can help to treat overactive bladder)

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9
Q

What medically-usable effects do alpha 1 agonists have?

A 
vasoconstriction to treat septic shock 
nasal decongestion (by constriction of vessels in the nose)
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10
Q

what medically usable effect does an alpha 2 agonists have

A

clonidine - lowers BP

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11
Q

What do alpha 1 blockers do?

A

doxazosin - reduces BP

tamsulosin - helps urination in benign prostatic hypertrophy

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12
Q

are there any useful alpha 2 blockers?

A

no

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13
Q

what are beta 1 agonists used for?

A

increasing heart rate and force of contraction

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14
Q

What are beta 2 agonists used for?

A

bronchodilation and delays onset of premature labour

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15
Q

what can beta 3 agonists be used for

A

treating overactive bladder

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16
Q

What are beta blockers used for and give some examples?

A 
proanolol, atenolol, bisoprolol and metoprolol - reduce BP, reduce cardiac work and treat arrhythmias 
angina
MI prevention
high BP
anxiety
arrythmias
heart failure
17
Q

what is one of the main problems with beta blockers?

A

broncocontriction in asthma and COPD

18
Q

what are the side effects of beta blockers?

A 
tiredness
cold extremities
bronchocontriction
bradycardia
hypoglycaemia
cardiac depression
19
Q

name a drug that blocks NA synthesis and what is it used for?

A

methyldopa - used (as a last resort) to treat high BP and so can be used in pre-eclampsia and eclampsia

20
Q

How do MAOIs work and what are they used for?

A

prevent the breakdown of dopamine/noradrenaline and so are used to treat depression

Pharmacology (10 decks)

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