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Pharmacology Exam 2 > Adrenergic Pharmacology > Flashcards

Adrenergic Pharmacology Flashcards

1
Q

Classical Non-Selective Beta Blockers (first gen)

A 
Nadolol (long half life)
Penbutolol (high lipid solubule)
Pindolol (intrinsic agonist activity - highest)
Propanolol (high lipid solubility)
Timolol (eye gtt)
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2
Q

Beta1 Selective Blockers (second gen)

A 
Acebutelol
Atenolol
Bisoprolol
Esmolol (ultra short half life - 10 mins)
Metoprolol (mod lipid soluble)
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3
Q

Non-selective Beta blockers with additional actions (third gen)

A

Carteolol
Labetalol (SYSTEMIC - block alpha 1)
Carvedilol (SYSTEMIC - block alpha 1, block Ca2+ entry), mod lipid soluble)

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4
Q

Beta 1 Selective Blockers with additional actions (third gen)

A

Betaxolol
Celiprolol (not in US)
Nebivolol (long half life)

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5
Q

Beta Blocker Toxicity/SEs

A

Bradycardia
Mild sedation
Cold hands
Vivid dreams
Depression (esp. in high lipid soluble - blood/brain barrier)
Nonselective: can worse pre-existing asthma)
Depressed myocardial contractility/excitability

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6
Q

Non-Selective Alpha Antagonists

A

Phenoxybenzamine

Phentolamine

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7
Q

Selective Alpha 1 Antagonists

A 
Prazosin
Terazosin
Doxazosin
Alfuzosin
Tamsulosin 
Indoramin
Urapidil 
Bunazosin
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8
Q

Selective Alpha 2 Antagonists

A

Yohimbine

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9
Q

Mixed Acting Adrenergic Agonists

A

Ephedrine: indirectly releases NE + directly stimulates receptors

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10
Q

Direct acting selective Adrenergic Agonists

A

A1: phenylephrine
A2: clonidine
B1: Dobutamine
B2: Terbutaline

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11
Q

Direct acting NON selective adrenergic agonists

A

A1,A2: oxymetazoline
B1,B2: isoproterenol
A1,A2;B1,B2: epinephrine
A1,A2;B1: norepinephrine

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12
Q

Indirect Acting Adrenergic Agonists

A

Releasing agents: amphetamine, tyramine
Uptake inhibitor: cocaine
MOA inhibitors: selegiline
COMT inhibitors: entacapone

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13
Q

Epinephrine vs Norepinephrine

A

HR
Epi > Norepi

Cardiac Output
Epi > Norepi

Cerebral/muscle blood flow
Epi > Norepi

Metabolic effects (glucose, O2 consuption, lactic acid, eosinopenic) 
Epi > Norepi

Peripheral vascular resistance
Norepi > Epi

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14
Q

Heart Rate

A

chronotropy

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15
Q

Contractility

A

ionotropy

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16
Q

Conduction between AV node

A

dromotropy

17
Q

Dopamine dosing/receptors

A

Low dose: dopaminergic @ kidneys (0.5-2 mcg/kg/min)
Medium: Beta 1 receptors (2-10 mcg/kg/min)
High: Alpha 1 (>10 mcg/kg/min)

18
Q

Short acting beta 2 agonists

A 
Metaproterenol (Alupent)
Albuterol (Ventolin)
Levalbuterol (Xopenex)
Pirbuterol (Maxair)
Terbutaline (Brethine) - tocolytic
19
Q

Long acting beta 2 agonists

A

Formoterol (Foradil)

Arformoterol (Brovena)

20
Q

Dopamine agonists

A

Levodopa: parkinson’s, prolactinemia
Fenoldopam: D1 agonist, peripheral vasodilation - treatment severe HTN

Pharmacology Exam 2 (1 decks)

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