Adrenergic drugs- direct-acting Non Catecholamines

Question 1

Category of Phenylephrine

Answer 1

a1 agonist (a1 > a2)

Question 2

Indication of Phenylephrine

Answer 2

Nasal (rhinitis) decongestant

Question 3

MoA of Phenylephrine

Answer 3

Systemically ↑ mean BP via vasoconstriction.

Question 4

PK/PD of phenylephrine

Answer 4

1) ↑ BP may elicit a reflex bradycardia.
2) Cardiac output may be ↓ but also offset by ↑ venous return.

Question 5

Adverse effects of Direct-acting Non- Catecholamines

Answer 5

1. Anxiety or euphoria.
2. Drowsiness or insomnia.
3. Hypotension or hypertension (a2 withdrawal)
4. Angina.
5. Palpitations and arrhythmias
6. Cardiac arrest.

Question 6

Category of Clonidine and Methyldopa

Answer 6

a2 agonist

Question 7

Indication of Clonidine and Methyldopa

Answer 7

Mild/ Moderate hypertension

Question 8

MoA of Clonidine and Methyldopa

Answer 8

Stimulate prejunctional receptors in CNS to
decrease sympathetic Methyldopa outflow

Question 9

Category of Isoproterenol

Answer 9

Non-selective β agonist

Question 10

Indication of Isoproterenol

Answer 10

1) ↑ HR and
2) ↓ mean BP
via vasodilation

Question 11

MoA of Isoproterenol

Answer 11

Systemically, ↓ mean BP via vasodilation (β2) and ↑ HR (β1)

Question 12

PK/PD of isoproterenol

Answer 12

β1 = β2

Question 13

PK/PD of Dobutamine

Answer 13

β1 > β2

Question 14

Indication of Dobutamine

Answer 14

Congestive heart failure

Question 15

MoA of Dobutamine

Answer 15

Systemically, ↓ mean BP via vasodilation (β2) and ↑ HR (β1)

Question 16

Category of Dobutamine

Answer 16

Non-selective β agonist

Question 17

Category of Salmeterol

Answer 17

Selective β2 agonists (β2 > β1)

Question 18

Indication of Salmeterol

Answer 18

long-term asthma and/or COPD.

Question 19

Category of Albuterol (aka Salbutamol)

Answer 19

Selective β2 agonists (β2 > β1)

Question 20

Indication of Albuterol (aka Salbutamol)

Answer 20

Acute asthma and/or COPD.

Question 21

Route of administration of Albuterol

Answer 21

Inhaled drugs;
–> gradual absorption from bronchi
–> lower drug level in body.

Question 22

Category of Terbutaline

Answer 22

Selective β2 agonists (β2 > β1)

Question 23

Indication of Terbutaline

Answer 23

1. Asthma
2. Premature labor