Adrenergic drugs- direct-acting Non Catecholamines Flashcards
Category of Phenylephrine
a1 agonist (a1 > a2)
Indication of Phenylephrine
Nasal (rhinitis) decongestant
MoA of Phenylephrine
Systemically ↑ mean BP via vasoconstriction.
PK/PD of phenylephrine
1) ↑ BP may elicit a reflex bradycardia.
2) Cardiac output may be ↓ but also offset by ↑ venous return.
Adverse effects of Direct-acting Non- Catecholamines
- Anxiety or euphoria.
- Drowsiness or insomnia.
- Hypotension or hypertension (a2 withdrawal)
- Angina.
- Palpitations and arrhythmias
- Cardiac arrest.
Category of Clonidine and Methyldopa
a2 agonist
Indication of Clonidine and Methyldopa
Mild/ Moderate hypertension
MoA of Clonidine and Methyldopa
Stimulate prejunctional receptors in CNS to
decrease sympathetic Methyldopa outflow
Category of Isoproterenol
Non-selective β agonist
Indication of Isoproterenol
1) ↑ HR and
2) ↓ mean BP
via vasodilation
MoA of Isoproterenol
Systemically, ↓ mean BP via vasodilation (β2) and ↑ HR (β1)
PK/PD of isoproterenol
β1 = β2
PK/PD of Dobutamine
β1 > β2
Indication of Dobutamine
Congestive heart failure
MoA of Dobutamine
Systemically, ↓ mean BP via vasodilation (β2) and ↑ HR (β1)
Category of Dobutamine
Non-selective β agonist
Category of Salmeterol
Selective β2 agonists (β2 > β1)
Indication of Salmeterol
long-term asthma and/or COPD.
Category of Albuterol (aka Salbutamol)
Selective β2 agonists (β2 > β1)
Indication of Albuterol (aka Salbutamol)
Acute asthma and/or COPD.
Route of administration of Albuterol
Inhaled drugs;
–> gradual absorption from bronchi
–> lower drug level in body.
Category of Terbutaline
Selective β2 agonists (β2 > β1)
Indication of Terbutaline
- Asthma
- Premature labor
