Adrenergic Drugs Flashcards
Dobutamine
answer: activation of PLC in arteriolar smooth m
Why? NE activates alpha 1 receptors which are Gq
NE is direct acting and is adrenergic acting on sympathetics. Tyramine is indirect acting and works indirectly to release NE. The NE will then act on alpha1 receptors and cause vasoconstriction of BVs which increases BP.
Acetylcholine
Why? d/t Indirect reflex effect of alpha1-AR agonist drug
Answer: increase HR d/t direct cardiac effect of NE
Why? Atropine is muscarinic antagonist so we won’t have a decreased HR. Instead NE will cause an increased HR and NE is a direct acting adrenergic agonist.
Answer: NE plus phentolamine
Dobumatine is a selective B-1 agonist
NE is a alpha 1 & alpha 2 agonist & B1 agonist and phentolamine is a non selective alpha1 and alpha 2 antagonists
Answer: phentolamine-induced tachycardia
Propranolol is a non-selective B-blocker
A is wrong bc: Propranolol can stop mydriasis bc phenylephrine acts on alpha-1 receptors
B is wrong bc NE acts on a1=a2 and B1>>B2 receptors
C is correct bc Phentolamine is a non-selective alpha1 & alpha 2 antagonist
