Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CSPI 6 Cardiovascular Drugs > Adrenergic Drugs > Flashcards

Adrenergic Drugs Flashcards

1
Q

Albuterol

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Dobutamine

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Epinephrine

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Isoproterenol

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Metaproterenol

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Norepinephrine

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Terbutaline

A

Direct-acting Beta agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Epinephrine

A

Direct-acting Alpha agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ergot Alkaloids

A

Direct-acting Alpha agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Metaraminol

A

Direct-acting Alpha agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Methoxamine

A

Direct-acting Alpha agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Norepinephrine

A

Direct-acting Alpha agonist

Levophed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Phenylephrine

A

Direct-acting Alpha agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dobutamine

A

Direct-acting Alpha agonist

very weak alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Naphazoline, Oxymetazoline, Tetrahydrozoline, Xylometazoline

A

-peripheral Alpha 1 agonist for topical
vasoconstriction of nasal passages and red eyes
-central imidazoline receptor agonism like clonidine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Amphetamines

A

Indirect acting sympathomimetic
Induce release and prevent the reuptake of norepinephrine, dopamine, and to a lesser
extent, serotonin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Cocaine

A

Indirect acting sympathomimetic

Mainly prevents reuptake of all 3 transmitters into nerve terminals and also causes some release.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Methylphenidate

A

Indirect acting sympathomimetic

(Ritalin; Concerta) – same as cocaine but less potent.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Propylhexedrine

A

Indirect acting sympathomimetic

isomer of amphetamine; found in OTC Benzedrex nasal inhaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mephentermine

A

Indirect acting sympathomimetic
Wyamine) - Releases nor-epi; possibly small direct action on receptors. Used IV or IM to
maintain blood pressure during spinal anesthesia. Some sources say there is small direct action also.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Pemoline

A

Indirect acting sympathomimetic

(Cylert) - for ADHD.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Fenfluramine

A

Indirect acting sympathomimetic

(Pondimin) – appetite suppressant; releases and prevents reuptake of serotonin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Phenmetrazine

A

Indirect acting sympathomimetic

(Preludin) – suppressant; prevents reuptake of nor-epi and dopamine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Isocarboxazid

A 
MAO Inhibition
(Marplan) - Nonspecific MAO-A & B inhibition; antidepressant - short term use.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Tranylcypromine

A 
MAO Inhibition
(Parnate) - irreversible non selective MAOI for depression.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Phenelzine

A

MAO Inhibition

Nardil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Selegiline

A

MAO Inhibition

(Emsam transdermal patch) - irreversible MAO-B inhibitor for Parkinson’s disease.

28
Q

Pargyline

A

MAO Inhibition

off the market.

29
Q

Linezolid

A

MAO Inhibition

Antibiotic; reversible, nonselective MAO inhibitor action.

30
Q

Methylene Blue

A

MAO Inhibition

Potent, reversible MAO A inhibitor

31
Q

Dopamine

A

Mixed direct and indirect action
o Low dose (0.5 to 2 μg/kg/min) - Stimulates dopamine receptors that enhance renal blood flow
o Mid dose (2 to 20 μg/kg/min) - Directly stimulates beta1 receptors to increase strength of contraction
o High dose (20 to 50 μg/kg/min) - Releases nor-epi and has vasopresssor effect.

32
Q

Ephedrine

A

Mixed direct and indirect action

Primarily indirect release of nor-epi; may be some direct alpha 1 stimulations also.

33
Q

Pseudoephedrine

A

Mixed direct and indirect action
OTC decongestant with controls on availability due to use as starting material in illegal
synthesis of methamphetamine.

34
Q

Phenylpropanolamine

A

Mixed direct and indirect action
OTC diet aid; spikes in blood pressure pose risk of hemorrhagic stroke. Off the
market in 2009 but still found as an undeclared ingredient.

35
Q

Alpha-methyldopa

A

Alpha 2 agonist

(formerly Aldomet) - Outdated blood pressure med; incredibly still in use.

36
Q

Brimonidine

A

Alpha 2 agonist

-for glaucoma

37
Q

Clonidine

A

Alpha 2 agonist & central imidazoline receptors
-unknown which receptors mediate which effects.
(Catapress, Kapvay)

38
Q

Dexmedetomidine

A

Alpha 2 agonist
(Precedex) – Alpha 2 agonist with sedative properties; IV use such as sedation for
bronchoscopy.

39
Q

Guanabenz

A

Alpha 2 agonist
(formerly Wytensin)
–Alpha 2 agonist and central imidazoline receptors

40
Q

Guanfacine

A

Alpha 2 agonist

(Intuniv, Tenex) - Similar to clonidine; particularly good for ADHD; also for hypertension.

41
Q

Alfuzosin

A

Alpha blocker
(Uroxatral) - Selective alpha1 blocker that targets only prostate (and eye); increases urine flow in
prostatic hypertrophy

42
Q

Phentolamine

A

Alpha blocker
Nonselective, competitive block of alpha 1 and 2; IM or IV as toxicology antidote for
epinephrine extravasation; hypertensive crisis.

43
Q

Phenoxybenzamine

A

Alpha blocker
Nonselective, noncompetitive alpha blocker; orally to control symptoms from
pheochromocytoma (tumor secreting epi and nor-epi.

44
Q

Doxazosin

A 
Alpha blocker
(Cardura) - Nonselective alpha 1 blocker; increases urine flow in prostatic hypertrophy.
45
Q

Tamsulosin

A

Alpha blocker
(Flomax) - Selective alpha1 blocker that targets only prostate (and eye); increases urine flow in
prostatic hypertrophy

46
Q

Tolazoline

A

Alpha blocker
Direct-acting peripheral vasodilator with weak nonselective alpha-blocking properties; used for
persistent pulmonary hypertension in newborn; and aid for arteriography.

47
Q

Terazosin

A

Alpha blocker
(Hytrin) - Nonselective alpha 1 blocker; increases urine flow in prostatic hypertrophy; also used
for diastolic hypertension.

48
Q

Silodosin

A

Alpha blocker
(Rapaflo) - Selective alpha1 blocker that targets only prostate (and eye); increases urine flow in
prostatic hypertrophy

49
Q

Prazosin

A

Alpha blocker
(Minipress) - Alpha 1 selective antagonist for hypertension, erectile dysfunction; prostatic
hypertrophy.

50
Q

Drugs that have alpha blocking as a “side effect”

A

phenothiazines
atypical antipsychotics
labetalol
TCAs

51
Q

Acebutolol

A

B1 cardio-selective
Moderate membrane stabilizing
Partial agonist

t1/2 3-6 hr (Active metabolite with 3-8 hr half-life)

52
Q

Atenolol

A

B1 cardio-selective

Removable by dialysis

53
Q

Betaxolol

A

B1 cardio-selective

Main use is topical eye drops for glaucoma.

54
Q

Bisoprolol

A

B1 cardio-selective

55
Q

Carteolol

A

As eye drops only for glaucoma.

56
Q

Carvedilol

A

highly lipid soluble
Also alpha-1 blocker, so worse hypotension
in OD. Lowers BP without reflex tachycardia.

57
Q

Esmolol

A

B1 cardio-selective
t1/2 9 min
IV only, short acting; metabolized by plasma
esterase.

58
Q

Labetalol

A

Also alpha-1 blocker, so worse hypotension
in OD. Good for pre-eclampsia, hypertensive
crisis; also IV form.

59
Q

Levobunolol

A

As eye drops only for glaucoma.

60
Q

Metipranolol

A

As eye drops only for glaucoma.

61
Q

Metoprolol

A

B1 cardio-selective

Also IV form.

62
Q

Nebivolol

A

Highly lipid soluble

Active metabolite with 12 hr half-life.

63
Q

Pindolol

A

High Partial agonist
One of most potent beta blockers available;
also blocks inhibitory 5HT1a autoreceptors
which would allow more release of serotonin.

64
Q

Propranolol

A

High Membrane Stabilizing

Highly lipid soluble

65
Q

Sotalol

A

Also blocks potassium channels/Class III

antiarrhythmic; prolong QT interval.

66
Q

Timolol

A

Also topical use in eye; in many combo

products.

CSPI 6 Cardiovascular Drugs (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions