Adrenergic Drugs Flashcards
What is an adrenergic drug?
A drug that influences the actives of the SNS or the CNS adrenergic system
Mimic or inhibit the effects of neurotransmitter and hormones of adrenergic systems
- NE = neurotransmitter
- E = hormone
What’s the difference between adrenergic agonists and antagonists?
Adrenergic agonists activate adrenergic receptors
Adrenergic antagonists block adrenergic receptors
What’s the difference between a1 and a2 adrenergic receptors (location and function)?
a1
- Located on postsynaptic effector cells (vascular smooth muscle cells)
- Causes vasoconstriction of blood vessels, GI/bladder sphincters, and uterine contraction
- Causes ejaculation
a2
- Located on presynaptic nerve terminals
- Inhibit the release of NE from nerve endings
Both a1 and a2 response to NE and Epi
What’s the difference between B1 and B2 receptors (location and function)?
Both are located on postsynaptic effector cells
B1
- Located primarily on the heart
- Results in cardiac stimulation (increased contractility and increased heart rate)
B2
- Located on smooth muscle of the bronchioles, arteries/arterioles, and visceral organs
- Results in bronchial, and uterine smooth muscle dilation/relaxation
- GI decreased motility
- Results glycogenolysis (breakdown of glycogen to glucose in liver and skeletal muscles)
What is a catecholamine?
A substances that produces a sympathomimetic response (stimulation of sympathetic nerves)
Endogenous
- Epi, NE
Direct-acting sympathomimetic binds directly to adrenergic receptor
What are the inotropic, chronotropic, and dromotropic effects due to B1 adrenergic receptors?
B1 causes
Positive inotropic effect
- Increased force of contraction
Positive chronotropic effect
- Increased HR
Positive dromotropic effect
- Increased conduction through the AV node
What are some examples of drugs*
*Pseudoephedrine
Phenylephrine
- Used for mydriasis (pupil dilation)
What are some examples of alpha-adrenergic agonists?*
Epinhephrine
Oxymetazoline
Peh
