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DT II Exam 1 > Adrenergic drugs > Flashcards

Adrenergic drugs Flashcards

1
Q

Alpha 2 actions (3)

A

Decrease sympathetic outflow
Decrease NE release
Decrease Insulin

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2
Q

Beta 1 actions (3)

A

Heart (increase HR, Contractility, Conduction velocity)
Increase Renin (increase BP with Renin-Angiotensin system)
Increase Lipolysis

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3
Q

Beta 2 actions (5)

A 
Bronchodilation
Skeletal muscle vessel dilation
Increase Glycogenolysis/ Gluconeogenesis
Increase Insulin
Relax Uterus
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4
Q

Precursor of Dopamine, NE, Epinephrine

A

Tyrosine

TH> L-AADC> DBH> PNMT

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5
Q

Difference in NE and Epi receptor interaction

A

Epi interact with all

NE interact with all except B2

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6
Q

Most important in terminating action of neuronally released NE

A

Active reuptake of NE into nerve terminal

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7
Q

Most important in terminating circulating Catecholamine action

A

Peripheral metabolism

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8
Q

Major metabolic enzyme for catecholamines

A

MAO and COMT

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9
Q

Major metabolites of catecholamine metabolism (3)

A

VMA, Metanephrine, Normetanephrine

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10
Q

Metyrosine: action

A

Reduce NE and Epi in Pheochromocytoma (adrenal gland tumor)

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11
Q

Metyrosine: MoA

A

Inhibit Tyrosine hydroxylase

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12
Q

Tyramine: action and ADR

A

Induce release of NE/ Epi
Dietary constituent

Enhanced by MAOI= Hypertensive crisis

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13
Q

Amphetamine: action and ADR

A

Release of NE and Epi
CNS stimulation

CNS effects

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14
Q

Amphetamine: use

A

ADHD

Narcolepsy

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15
Q

Cocaine

A

Inhibit NE reuptake into nerve terminal

Increase NE effects

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16
Q

Tranylcypromine/ Phenelzine

A

= MAOI
enhance NE
Antidepressant mechanism

Hypertensive crisis (increased circulating dietary amine level with MAOI)

17
Q

Entacapone

A

COMT inhibitor

Adjunctive therapy for Parkinson with Levodopa/ Carbidopa

18
Q

Catecholamine: (5) and characteristics (4)

A 
Dopamine, Isoproterenol, NE, Epi, Dobutamine (DINED)
Short duration/ Rapidly metabolized
Not effective orally
Metabolized by COMT
OH on C3/4 of benzene ring
19
Q

Selective alpha 1 agonist

A

Phenylephrine

20
Q

Phenylephrine: effects, use, ADR

A

Mydriasis, Vasoconstrict (inc BP), reflex dec HR

Mydriatic, Decongestant, Prolong anesthetic effect (vasoconstri)

Hypertension (inc BP)

21
Q

Selective Alpha 2 agonist

A

Clonidine

22
Q

Clonidine: effect, use, ADR

A

dec BP, little reflex inc HR

Hypertension, Drug addiction ADHD

Hypertensive crisis with withdrawal, Sedation, Sex dysfunction

23
Q

Selective Beta 2 agonist

A

Albuterol

24
Q

Albuterol: action, use, ADR, contra

A

Bronchodilation, Vasodil> reflex inc HR

Reverse bronchospasm/ asthma

Cardiac stimulation, Tremor

Tachyarrhythmia, Hyperthyroidism

25
Q

B1 and B2 agonist

A

Isoproterenol

26
Q

Isoproterenol: action, use, ADR, contra

A

Bronchodilation, dec TPR, dec BP, inc HR

Bronchospasm, Cardiac arrest, Heart block

Cardiac stimulation, Tremor

Tachyarrhythmia, Hyperthyroidism

27
Q

All receptor agonist

A

Epinephrine

28
Q

Epinephrine, action, use, ADR, Contra

A

Bronchodilation, inc HR, low dose= dec TPR/BP, high dose= inc TPR/ BP {low- Beta dominates, high- alpha dominates}

Anaphylaxis, Bronchospasm, Cardiac arrest, Prolong anesthetic, Glaucoma

Hyperglycemia, Cardiac stimulation, Vasoconstriction, CNS stimulation

Tachyarrhythmia, Hyperthyroidism, MAOI increases toxicity

29
Q

All but B2 (A1, A2, A1)

A

Norepinephrine

Dopamine

30
Q

Norepinephrine: action, use, ADR, contra

A

inc TPR/ BP, normal HR

Septic/ cardiogenic shock

Cardiac effect, Vasoconstriction= Hypertension

Tachyarrhythmia, Hyperthyroidism, Hypertension, MAOI and Cocaine increases toxicity

31
Q

All but A2

A

Dobutamine

32
Q

Dobutamine: action, use, ADR

A

inc CO, normal HR/ TPR/ BP {for CHF patients}

Acute CHF

Arrhythmia, inc myocardial O2 consumption, inc AV node conduction, Hypertension

33
Q

Dopamine: MoA

A

D1 receptor agonist (dilate renal, splanchnic, cerebral, coronary vessels)
All but Beta 2

34
Q

Dopamine: action with doses

A

Low dose: Vasodilation of renal and splanchnic vessels

Moderate dose: dec TPR, normal BP, direct/ reflex B1= inc HR/ CO

High dose: inc TPR/ BP (alpha> D1), B1= inc HR/ CO

35
Q

Dopamine: use and ADR

A

Shock, Acute CHF

Tachyarrhythmia, Hyperthyroidism, Hypertension

36
Q

Pseudoephedrine

A

Vasoconstrict, normal HR

Decongestant (like phenylephrine (selective A1)

Insomnia, Hypertension

37
Q

Alpha 1 actions (4)

A

Mydriasis
Constrict vessel
Constrict GI/ GU
Sexual function

DT II Exam 1 (5 decks)

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