Adrenergic Blockers (antagonists) Flashcards
What is the response created by adrenergic blockers?
Response by blocking alpha and beta receptors
Mechanism of actions by adrenergic antagonist
Direct (occupying receptors) and indirect (inhibiting release of neurotransmitters) blocking
2 types of adrenergic blockers
Alpha and beta blockers
Alpha blockers?
Works by block binding of epi to smooth muscle that can relax it and can cause VASODILATION (that can help prevent hypertension and PVD)
Also, helps in contraction of the bladder and prostate
Suffix for the alpha blockers?
It usually ends with -zosin
What to remember when taking alpha blockers?
Alpha blockers can cause the ff:
- Dizziness
- Orthostatic hypotension (sudden decrease of bp and hr)
- Headache, nasal congestion
What is orthostatic hypotension and what intervention you can do for it?
Orthostatic hypotension is the sudden decrease of BP (SBP -20 mmHg and DBP -10 mmHg) and increase in HR 20 bpm
Usually happens when changing positions (supine-sitting or standing)
Intervention: from supine to sitting, dangle legs for 5 mins, then proceed in standing
Beta blockers?
Decreases heart rate and bp Can help in treating mild to moderate: Hypertension Angina pectoris (chest pain) Myocardial infarction (heart attack)
Suffix for beta blockers?
It usually ends with -olol
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Drug for hypertension?
Prazosin or terazosin
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Drug for BPH?
Tamsulosin or alfuzosin
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Drug for glaucoma?
(Glaucoma is group of disease that damages the optic nerve, build up of pressure)
Tumolol (1st gen)
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Drug for decrease CO, HR for patients with heart block?
Pindolol