Adrenal Steroids

Question 1

Properties of Prednisone

Answer 1

5x higher potency GC (than hydrocortisone), lower MC effects

Most common clinically for anti-inflammatory uses

Longer duration of action (24hr half-life)

Question 2

Properties of Dexamethasone

Answer 2

Very potent GC, almost no MC effects

Long drug duration

Low-dose effective (duh, high potency)

Question 3

Properties of Fludrocortisone

Answer 3

Synthetic MC drug, significant GC effects

Used when MC effects are desired such as replacement therapy in adrenal failure and in 21-hydroxylase deficiency

Question 4

Uses and properties of Spironolactone

Answer 4

I hate this drug.

MC receptor ANTAGONIST - therefore a diuretic

Also has hormone effects (ya think?)

Question 5

Properties of hydrocortisone

Answer 5

Low potency GC, with some MC effects

Used for mild-inflammation

Short duration of action