Adrenal Physiology Flashcards
what are the two main parts of the adrenal glands
medulla (inside)
cortex (outside)
What 3 areas make up the cortex
Zona glomerulosa
Zona fasciculata
Zona reticularis
What does the zona glomerosa secrete
mineralocorticoids (aldosterone)
what does the zona fasciculata secrete
glucocorticoids
what doses the zona reticularis secrete
adrenal androgens
what regulates the secretion of mineral corticoid
Angiotensin 2
K+
What regulates the secretion of glucocorticoids and adrenal androgens
ACTH
when is angiotensin 2 produced
in response to a drop in blood pressure as it leads to direct vasoconstriction and indirect (aldosterone) methods of BP elevation
how do steroids work
bing to receptor
receptor/ligand complex binds to DNA to affect transcription
what are the major actions of glucocorticoid
increased CO
increased BP
Increased renal blood flow and GFR
increased blood glucose
increased lipolysis
increased proteolysis
accelerates osteoporosis poor wound heeling decreased calcium decreased decreased collagen formation
effects on mood and libido
decreased capillary dilation/permeability
decreased leucocyte migration
decreased macrophage activity
decreased inflammatory cytokine production
what are the 3 main reasons to use corticosteroids
suppress inflammation
suppress immune system
replacement treatment
what are the effects of aldosterone via the mineralocorticoid receptor
increased sodium reabsorption
K+/H+ excretion
blood pressure regulation
regulation of extracellular volume
