Adrenal Modulation Flashcards
1
Q
Hydrocortisone
A
- .3-.5 days
- 1:1 glucocorticoid and mineralocorticoid
- Hydroxy at 11 needed for any activity
2
Q
Prednisone-Prednisolone
A
- About .5-1 days
- Mostly glucocorticoid, some mineralocorticoid
- Carbonyl at 11– needs special enzyme not found in skin to activate
- Double Bond at C1=C2, more anti-inflammatory
3
Q
Dexamethasone
A
- Long acting 1-1.5 days
- All glucocorticoid (potent)
- Fluorine at C9 AND alpha-methyl carbon at C-16 (removes mineralocorticoid effects)
4
Q
Fludrocortisone
A
- Longer acting aldosterone analogue
- From flourine at C9
5
Q
Triamcinolone
A
About 5/8-1 days
-Fairly potent anti-inflammatory
6
Q
Methylprednisolone
A
- More potent anti-inflammatory than cortisol
- From alpha-methyl at C16
