ADPKD Flashcards
1
Q
What percentage of patients with ADPKD will require dialysis at 60 years of age?
A
~50%
2
Q
What percentage of patients with ADPKD have a mutation at the PKD-1 locus on chromosome 16?
A
85%
3
Q
What percentage of patients with ADPKD will have mitral valve prolapse?
A
25%
4
Q
What % of patients with ADPKD have an asymptomatic intracranial aneurysm?
A
8%
5
Q
What is PKD-1?
A
It is a relatively large cell surface protein that is involved in mechanosensation for fluid flow in the renal tubules.
6
Q
What genetic cause of DM is associated with renal cysts and liver cysts?
A
MODY 5
7
Q
A
