ADME Flashcards
Pharmacokinetics definition
the study of time course of ADME of drugs from biological systems and monitoring the concentration of drug as it travels in the body (rate of ADME)
Elimination
Metabolism + excretion
The process that lead to the entry of the drug to the systemic circulation of the body
Absorption
The major considerations that account for absorption a drug.
Administration route
The movement of a drug to and from the blood and various tissues of the body, and the relative proportions of drugs in the tissues.
Distribution
Parameter for Distribution
Volume of Distribution
The process which the drug is biochemically modified through specialized enzymatic systems
Metabolism
Major site for metabolism
Liver
Alteration of chemical structure of a drug that is imposed by the life sciences
Biotransformation (often lipophilic chemical compounds are converted into hydrophilic products so that can be readily excreted)
Ideal drug candidate
Transported by the body fluids
Traverse biological membrane barriers
Escape widespread distribution
Endure metabolic attack
Penetrate in adequate concentration to the sites of action
interact in specific fashion causing an alteration of cellular function.
MEC
Minimum effective Concentration
MTC
Maximum tolerated Concentration
AUC
area under curve = total exposure to drug
Onset Time
Time at MEC starts
Duration of Action
How much time does the drug remains active (from onset to offset)
